Scarlet fever pathogen draft genome sequence released

June 22, 2011

Scarlet fever has revealed unusual high infect rate in Hong Kong this year. So far, 466 children were infected and 2 of them dead. Scarlet fever is caused by Streptococcus pyogenes, a gram-positive pathogen that can be transmitted via skin wound and airborne droplet.

Under the guidance of Hong Kong Center for Disease Control (HK ), Hong Kong University (HKU) and their partners today released the draft genome sequence of the S. pyogenes strain that was isolated from a scarlet fever patient (Sequence has been uploaded to NCBI AN: SRA038808 and is available for immediate download at ftp://ftp.genomics.org.cn/pub/S.pyogenes/). Current analysis results indicate that this strain belongs to M12 serotype, which was widely distributed in Europe, North America, South America, and Asia. No significant characters were observed on this type of S. pyogenes strain. There is 95.2% genomic region of this strain can be aligned to two previously fully sequenced M12 and 4.8% (around 90 kbp) is specific to this strain. It is possible that the specific sequences in this strain may result in the increase of virulence and improved spread ability.

HKU and their collaborators are continuing on the intense research of this pathogen. The whole genome fine map of this S. pyogenes will be released within a week. The team will further explore the source of the specific virulent-related sequences and possible pathogenicity mechanism by comparing the previous S. pyogenes isolates in Hong Kong and the current sequenced strain. The research results will provide scientific evidences to facilitate the control of the infectious rate as well to develop effective measures to prevent the spread of scarlet fever.

It is reported that the draft genome sequence and preliminary analysis results were accomplished by HKU and BGI-HongKong. Earlier this month, BGI-Shenzhen and University Medical Centre Hamburg-Eppendorf worked together to firstly develop the complete whole of the Germany Escherichia coli outbreak strain.

Explore further: Brucella abortus S19 genome sequenced; points toward virulence genes

Related Stories

Hong Kong bird tests positive for H5N1

March 6, 2009

Hong Kong authorities said Friday that a dead chicken found in the southern Chinese territory had tested positive for the deadly H5N1 strain of the bird flu virus.

The complete map of the Germany E. coli O104 genome released

June 16, 2011

Building upon previous efforts producing a high-quality de novo genome assemblies of deadly 2011 E. coli O104:H4 outbreak strain (http://www.genomics.cn/en/news_show.php?type=show&id=651), the BGI and their collaborators ...

Hong Kong declares scarlet fever outbreak

June 21, 2011

Hong Kong has declared an outbreak of scarlet fever after it claimed the life of at least one child while infecting thousands of others in the city and elsewhere in China.

Recommended for you

How nature punches back at giant viruses

September 4, 2015

(Phys.org)—What have viruses ever done for humans? The question is debatable, but given the prevalence of highly contagious, and sometimes life-threatening illnesses caused by viruses, it's fair to say that most people ...

Secrets of a heat-loving microbe unlocked

September 4, 2015

Scientists studying how a heat-loving microbe transfers its DNA from one generation to the next say it could further our understanding of an extraordinary superbug.

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.