Mechanism behind compound's effects on skin inflammation and cancer progression

May 23, 2011

Charles J. Dimitroff, MS, PhD and colleagues in the Dimitroff Lab at Brigham and Women's Hospital, have developed a fluorinated analog of glucosamine, which, in a recent study, has been shown to block the synthesis of key carbohydrate structures linked to skin inflammation and cancer progression. These findings appear in the April 14, 2011, issue of the Journal of Biological Chemistry.

Dr. Dimitroff and colleagues show for the first time that the fluorinated glucosamine therapeutic works not through direct incorporation into growing sugar chains as previously believed but instead blocks the synthesis of a key sugar, UDP-GlcNAc, inside immune cells characteristically involved inflammation and anti-tumor immunity

Accordingly, this report underscores a novel and previously unknown mechanism by which fluorinated glucosamine analogs could shape and reduce inflammation intensity, while boosting anti-tumor immune responses. Such knowledge could prove valuable in the design of new and more potent glucosamine mimetics against disease as well as in treatment strategies to utilize existing glucosamine mimetics more efficiently.

Explore further: Glucosamine-like supplement inhibits multiple sclerosis, type 1 diabetes

Related Stories

Glucosamine causes the death of pancreatic cells

October 27, 2010

High doses or prolonged use of glucosamine causes the death of pancreatic cells and could increase the risk of developing diabetes, according to a team of researchers at Universite Laval's Faculty of Pharmacy. Details of ...

Recommended for you

Findings illuminate animal evolution in protein function

July 27, 2015

Virginia Commonwealth University and University of Richmond researchers recently teamed up to explore the inner workings of cells and shed light on the 400–600 million years of evolution between humans and early animals ...

Bleach a possible key to life on earth

July 23, 2015

Hydrogen peroxide - commonly used as hair bleach - may have provided the energy source for the development of life on Earth, two applied mathematicians have found.

Acetic acid as a proton shuttle in gold chemistry

July 24, 2015

A recently published study gives a vivid example of unusual chemical reactivity associated with organogold complexes. Using modern physical methods and computational studies, the authors propose a reaction mechanism in which ...

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.