Discovery of cis-4-Hydroxy-L-proline, a material of pharmaceutical, cosmetic products

May 18, 2011
Discovery of cis-4-Hydroxy-L-proline, a material of pharmaceutical, cosmetic products

Discovery of the new enzyme, available for manufacturing of cis-4-Hydroxy-L-proline, a material of pharmaceutical and cosmetic products.

Prof. Kuniki Kino (Department of Applied Chemistry, Faculty of Science and Engineering) and Dr. Ryotaro Hara (Research Institute for Science and Engineering) have discovered New Enzyme, which contributes establish an innovative new industrial manufacturing method for cis-4-hydroxy-L-proline, an amino acid derivative.

cis-4-Hydroxy-L-proline is a kind of amino acid which is hydroxylated in the 4-position of L-proline and it is believed to have potential as a raw material for pharmaceutical and . trans-4-Hydroxy-L-proline , a cis-4-hydroxy-L-proline stereoisomer , has been used for a broad range of applications since an efficient fermentation production method was established by KYOWA HAKKO BIO CO., LTD. in 1997. cis-4-Hydroxy-L-proline, however, could only be manufactured through a complex chemical synthetic procedure, and due to the high costs involved, usage has been limited.

Using a new that positionally and stereoscopically hydroxylates L-proline discovered by Prof. Kino and Dr. Hara, KYOWA HAKKO BIO has established an efficient industrial production method for cis-4-hydroxy-L-proline. As a result, they are now able to steadily supply highly pure cis-4-hydroxy-L-proline at a low cost. Further, they now have the technology to cheaply produce a variety of highly pure proline .

Waseda University, as a “Research University”, keeps contributing to the development of industry through promoting Research collaborations.

Explore further: Four billion-year-old chemistry in cells today

add to favorites email to friend print save as pdf

Related Stories

Stretchy spider silks can be springs or rubber

May 31, 2008

It’s stronger than steel and nylon, and more extensible than Kevlar. So what is this super-tough material? Spider silk; and learning how to spin it is one of the materials industries’ Holy Grails. John Gosline has been ...

Researchers unveil a new class of fatty acids

Apr 28, 2008

CSIRO researchers have discovered a new class of fatty acids – alpha-hydroxy polyacetylenic fatty acids – that could be used as sensors for detecting changes in temperature and mechanical stress loads.

Recommended for you

Nature inspires a greener way to make colorful plastics

17 hours ago

Long before humans figured out how to create colors, nature had already perfected the process—think stunning, bright butterfly wings of many different hues, for example. Now scientists are tapping into ...

New catalyst converts carbon dioxide to fuel

18 hours ago

Scientists from the University of Illinois at Chicago have synthesized a catalyst that improves their system for converting waste carbon dioxide into syngas, a precursor of gasoline and other energy-rich products, bringing ...

Bullet 'fingerprints' to help solve crimes

18 hours ago

Criminals don't just have to worry about their own fingerprints these days: because of a young forensic scientist at The University of Western Australia, they should also be very concerned about their bullets' ...

User comments : 0