Antibody production gets confused during long-term spaceflight

"We hope to find efficient pharmacological and/or nutritional countermeasures to alterations of the immune system that could be useful to astronauts and to people who have weak immune systems on Earth because of infections, aging, or chronic stress exposure," said Jean-Pol Frippiat, a researcher involved in the work from the Faculty of Medicine, Development and Immunogenetics at the Université Henri Poincaré-Nancy, Vandœuvre-lès-Nancy, France.

To make their discovery, Frippiat and colleagues conducted studies using three groups of amphibians. Amphibians were chosen for the work because they use the same cellular mechanisms to produce antibodies as humans do. The first group of amphibians was immunized in space, the second was immunized on Earth, and the third was not immunized at all. Comparison of the antibodies produced revealed that the quality of the antibodies generated by the group immunized in space was decreased. This suggests that spaceflight conditions alter the immune system and affect its ability to protect against infections and tumors, posing a serious risk for astronauts.

"This paper shows that somatic hypermutation occurs at a lower frequency in spaceflight and brings together yet more evidence that the immune system is dependent on gravity," said Millie Hughes-Fulford, Ph.D., NASA Science Astronaut; Professor, Department of Biochemistry and Biophysics, UCSF; Director, Laboratory of Cell Growth, VAMC/UCSF; and editorial board member of the FASEB Journal. "Dependence on gravity should be no surprise since all of earth's jawed vertebrates developed in earth's gravity, and it would be logical to expect that some systems would require gravity for normal function."

"Outer space may be the final frontier, but this research shows that our inner space could pose the greatest threat to the success of a mission," said Gerald Weissmann, M.D., Editor-in-Chief of the FASEB Journal. "These explorers will have to be prepared not only for the challenges of extremely hostile environments, but also those posed by microbial stowaways, even those with which we peacefully co-exist on Earth."

More information: Matthieu Bascove, Nathan Guéguinou, Bérénice Schaerlinger, Guillemette Gauquelin-Koch, and Jean-Pol Frippiat. Decrease in antibody somatic hypermutation frequency under extreme, extended spaceflight conditions. FASEB J. published ahead of print, May 18, 2011, doi: 1096/fj.11-185215

Provided by Federation of American Societies for Experimental Biology