Giant fire-bellied toad's brain brims with powerful germ-fighters

Apr 13, 2011

Frog and toad skins already are renowned as cornucopias of hundreds of germ-fighting substances. Now a new report in ACS's Journal of Proteome Research reveals that the toad brains also may contain an abundance of antibacterial and antiviral substances that could inspire a new generation of medicines.

Ren Lai and colleagues point out that scientists know little about the germ-fighting proteins in amphibian brains, despite many studies showing that amphibians synthesize and secrete a remarkably diverse array of antimicrobial substances in their skin. So they decided to begin filling that knowledge gap by analyzing brains from the Giant Fire-Bellied Toad and the Small-webbed Bell Toad.

They discovered 79 different antimicrobial peptides, the components of proteins, including 59 that were totally new to science. The diversity of the peptides "is, to our knowledge, the most extreme yet described for any animal brains," they noted. Some of the peptides showed strong antimicrobial activity, crippling or killing strains of staph bacteria, E. coli, and the that causes yeast infections in humans. These promising findings suggest that the toad brains might be a valuable source for developing new antibacterial and .

Explore further: Researchers create first inhibitor for enzyme linked to cancers

add to favorites email to friend print save as pdf

Related Stories

Marijuana ingredients show promise in battling superbugs

Sep 08, 2008

Substances in marijuana show promise for fighting deadly drug-resistant bacterial infections, including so-called "superbugs," without causing the drug's mood-altering effects, scientists in Italy and the United Kingdom are ...

Recommended for you

New computer model sets new precedent in drug discovery

Nov 18, 2014

A major challenge faced by the pharmaceutical industry has been how to rationally design and select protein molecules to create effective biologic drug therapies while reducing unintended side effects - a challenge that has ...

Finding new ways to make drugs

Nov 18, 2014

Chemists have developed a revolutionary new way to manufacture natural chemicals and used it to assemble a scarce anti-inflammatory drug with potential to treat cancer and malaria.

User comments : 0

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.