Genetic changes behind sweet tooth
The substance ghrelin plays an important role in various addictions, such as alcoholism and binge-eating. It also impacts on sugar consumption, which is due, in part, to genetic factors, reveals new research from the University of Gothenburg, Sweden.
Ghrelin is a neuropeptide that both activates the brain's reward system and increases appetite. This means that when we are hungry, levels of ghrelin increase, activating the brain's reward system, and this, in turn, increases our motivation to look for food. Previous research from the Sahlgrenska Academy has linked ghrelin to the development of various dependencies, such as drug addiction and alcoholism.
In a new study published in the online version of the journal Plos One, researchers examined the genes of 579 individuals chosen from the general public. It emerged that people with certain changes in the ghrelin gene consume more sugar than their peers who do not have these changes. This link was also seen in people who consumed large amounts of both sugar and alcohol.
Trials have also been carried out using rats, where the researchers found that when ghrelin was blocked the rats reduced their consumption of sugar and were less motivated to hunt for sugar.
"This shows that ghrelin is a strong driver when it comes to tracking down rewarding substances such as sugar or alcohol," says researcher Elisabet Jerlhag from the Sahlgrenska Academy's Department of Pharmacology.
These results go hand in hand with the researchers' previous findings which showed that substances that block the ghrelin system reduce the positive effects of addictive drugs and that changes in the ghrelin gene are associated with high alcohol consumption, weight gain in alcoholics and smoking.
The researchers are now a step closer to understanding what happens in the brain and the body in different types of addictive behavior. Understanding these mechanisms means that new drugs can be developed to block the ghrelin system and used to treat patients who are addicted to alcohol or who suffer from binge-eating disorders.
"This knowledge could also make it easier for society to view dependency as an illness and could mean that these people can get the treatment they need more readily," says Jerlhag.
Provided by
University of Gothenburg
-
From lemons to lemonade: Reaction uses carbon dioxide to make carbon-based semiconductor,
32 comments
-
Thioridazine kills cancer stem cells in human while avoiding toxic side-effects of conventional cancer treatments,
3 comments
-
SpaceX private rocket blasts off for space station (Update),
42 comments
-
Climate scientists say they have solved riddle of rising sea,
30 comments
-
Research team claims to have found evidence Lake Cheko is impact crater for Tunguska Event,
18 comments
-
Classical and Quantum Mechanics via Lie algebras
Apr 15, 2011
- More from Physics Forums - Independent Research
More news stories
Keep food safety in mind this memorial day weekend
(HealthDay) -- Picnics, parades and cookouts are as much a part of Memorial Day weekend as tributes to the United States' war veterans.
10 hours ago |
not rated yet |
0
Family history of Alzheimer's affects functional connectivity
(HealthDay) -- Cognitively normal individuals with a family history of late-onset Alzheimer's disease (AD) may display lower resting state functional connectivity in the default mode network (DMN) of the brain, ...
Medicine & Health / Alzheimer's disease & dementia
19 hours ago |
not rated yet |
0
Transvaginal mesh op restores pelvic organ prolapse at price
(HealthDay) -- Transvaginal mesh (TVM) procedures are effective for anatomical restoration of pelvic organ prolapse (POP), but patients report a worsening of sexual function following surgery, according to ...
19 hours ago |
not rated yet |
0
Travel to high altitudes tied to Crohn's, colitis flare-ups
(HealthDay) -- People with inflammatory bowel disease, which includes Crohn's disease and colitis, may be at increased risk for flare-ups when they fly or travel to high altitudes for skiing or mountain climbing, ...
Medicine & Health / Inflammatory disorders
20 hours ago |
not rated yet |
1
|
Weight struggles? Blame new neurons in your hypothalamus
New nerve cells formed in a select part of the brain could hold considerable sway over how much you eat and consequently weigh, new animal research by Johns Hopkins scientists suggests in a study published in the May issue ...
Medicine & Health / Neuroscience
May 21, 2012 |
5 / 5 (1) |
6
|
Scientist: Evolution debate will soon be history
(AP) -- Richard Leakey predicts skepticism over evolution will soon be history. Not that the avowed atheist has any doubts himself.
Dell tablet leak: 10.1-inch display, two-battery choice
(Phys.org) -- Headline after headline talks about vendors’ tablets in the wings as likely number-one contenders for the iPad. Such claims have justifiably been taken with a grain of salt, considering ...
SpotterRF debuts Radar Backpack Kit (w/ Video)
(Phys.org) -- SpotterRF has announced a special radar backpack kit designed to enhance situational awareness for soldiers on the ground. The company says its special radar is designed for warfighters as part ...
SpaceX capsule has 'new car' smell, astronauts say (Update)
SpaceX's Dragon cargo vessel smells like a new car, said astronauts at the International Space Station after opening the hatches Saturday following the spacecraft's landmark mission to the orbiting lab.
Thousands of shellfish found dead in Peru
Thousands of crustaceans were found dead off the coast of Lima following the mystery mass death of dolphins and pelicans, the Peruvian Navy said Friday.
Astronomers seize last chance in lifetime for Venus Transit
Astronomers are gearing for one the rarest events in the Solar System: an alignment of Earth, Venus and the Sun that will not be seen for another 105 years.
