Firm uses genetic modification to coax spider silk from silkworms

Apr 14, 2011 by Bob Yirka report

(PhysOrg.com) -- In what many in the textile industry have for years been calling the holy grail of materials science, genetic engineers from Kraig Biocraft Laboratories Inc. have succeeded, using Sigma Life Science technology, in creating genetically modified silkworms that are able to produce a silkworm/spider silk combination that is much stronger and more elastic than natural silk, paving the way for improved products such as sutures, other medical devices and even airbags.

The effort, conducted with research partners from the University of Notre Dame and the University of Wyoming, strove to combine the advantages of created by , with silk created by . Spiders create webs from silk that has a very high tensile strength and is very elastic; it can be stretched to almost one and a half times its own length without a problem; but unfortunately, spiders aren’t big producers of such silk, needing only to create a simple web. Silkworms on the other hand are big producers of silk, due to their natural inclination to use it for creating a cocoon. Thus, it was deduced, if silkworms could be induced to create the same kind of silk as spiders, and at the same rate they normally produce regular silk, we humans could benefit by garnering rapidly produced strong silk.

The research was led by Malcolm J. Fraser Jr., professor of biological sciences at Notre Dame and was founded on a process he has developed called the piggyBac, which is where a piece of DNA can be made to insert itself into the genetic material of a cell. Used in conjunction with Sigma's proprietary CompoZr® Zinc Finger Nuclease (ZFN) technology, genes were transferred to silkworm cells, causing silkworms to produce a type of silk that is a combination of their natural silk, and that of the silk produced by a spider. The new silk, as yet unnamed, is far stronger and more flexible than any other silk ever produced by silkworms and the researchers believe that by removing some of the DNA material from the silkworm genes prior to the addition of spider material, they can produce something even better in the near future.

Because techniques have already been developed for producing mass quantities of regular silk using silkworms, all of the parties involved are confident that they will soon be able to produce a silk so strong it might one day replace Kevlar in bullet proof vests, or provide surgeons with sutures strong enough, and elastic enough to allow them to perform life-saving procedures in far less time. It’s possible that one day this new super-silk might make regular silk something that’s only used for creating very soft comfortable clothes.

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User comments : 7

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jscroft
1 / 5 (1) Apr 14, 2011
Why does this read like an advertisement, hmmm? There's a spam button for comments; maybe we need one for articles as well.
Objectivist
5 / 5 (1) Apr 14, 2011
Why does this read like an advertisement, hmmm? There's a spam button for comments; maybe we need one for articles as well.

Except this is quite an accomplishment worth mentioning. In case you didn't know a lot of research in the world is privately funded.
J-n
5 / 5 (1) Apr 14, 2011
While i think that this article does talk about a MAJOR advance in silk techonology, and shows another genetic modification success. I will say that with the lack of hard numbers (How much more elastic, strong etc is the silk, how much stronger, elastic do they think they can make it, how does it compare to kevlar that they say it could one day replace... etc etc etc) that it does seem much more like a press release created to garner financial support (investors, advance sales) than it is to inform on a scientific level.

So i guess i can safely say that i agree with both jscroft and Objectivist on this one.
Sin_Amos
not rated yet Apr 14, 2011
This is so old.
Parsec
not rated yet Apr 15, 2011
Do you guys have any idea what impact this can have on our society? Access to tons of spider silk will turn the textile industry on its head. Any progress at all in convincing silkworms to create more spider like silk is amazing.
Djincss
not rated yet Apr 15, 2011
All I see is GM smallheads haters pissed off hahahaahaa
Like it or not we will see tons and tons of new GMOs, which are more environmental friendly, smart and everything, so better use to it than to trow...punks.
Wolf358
not rated yet Apr 15, 2011
"Spilk"