New therapeutic target for lung cancer

Mar 31, 2011

A new therapeutic target for lung cancer has been discovered by researchers at Seoul National University. It was found that a variant of the protein AIMP2 is highly expressed in lung cancer cells and also that patients demonstrating high expression of this variant show lower survival. The study is published on March 31 in the open-access journal PLoS Genetics.

Lung cancer is one of the world's most common cancers and a leading cause of death resulting from cancer. Despite treatment with a combination of surgery, radiation and drugs, the survival rate for patients has not drastically improved over the past few decades. It had previously been shown that the protein AIMP2 acted as a tumor-suppressor by interacting with another oncosuppressor, . However, whether AIMP2 was indeed pathologically linked to human cancer had not been definitively proved. This investigation discovered that a variant of AIMP2 is highly expressed in human lung cancer cells. AIMP2-DX2 compromises the tumor-suppressing activity of AIMP2 by competitively binding to p53. It was also shown that suppression of AIMP2-DX2 slowed , suggesting that this could be an exciting new therapeutic target.

New innovative therapies are important not only because of the high mortality rate associated with , but because the majority of the drugs are cytotoxic, causing many adverse effects. These findings could create an opportunity to develop new innovative , as well as presenting a new target that could also be applied to other cancers.

Explore further: Lung cancer test less effective in areas where infectious lung disease is more common

More information: Choi JW, Kim DG, Lee A-E, Kim HR, Lee JY, et al. (2011) Cancer-Associated Splicing Variant of Tumor Suppressor AIMP2/p38: Pathological Implication in Tumorigenesis. PLoS Genet 7(3): e1001351. doi:10.1371/journal.pgen.1001351

add to favorites email to friend print save as pdf

Related Stories

Protein is linked to lung cancer development

Oct 22, 2009

(PhysOrg.com) -- A protein that normally helps defend cells from infection can play a critical role in the development of lung cancer, according to MIT cancer biologists.

CXCR4: A new drug target in lung cancer

Apr 29, 2010

Lung cancer patients whose tumors over-express a cell surface molecule called CXCR4 do significantly worse than those who do not, Canadian researchers have found. Their work, reported at the 2nd European Lung Cancer Conference ...

Recommended for you

XenOPAT, mouse models for personalized cancer treatment

12 hours ago

On September 8th, the company XenOPAT SL, a spin-off of the Institute of Biomedical Research (IDIBELL) and the Catalan Institute of Oncology (ICO) was established with the aim of bringing the company the latest scientific ...

User comments : 0