Probiotic bacteria could help treat Crohn's disease

Mar 31, 2011

New research suggests that infection with a probiotic strain of E. coli bacteria could help treat an reduce the negative effects of another E. coli infection that may be associated with Crohn's disease. Researchrs from the University of Auckland, New Zealand publish their results in the April 2011 issue of the journal Applied and Environmental Microbiology.

Crohn's disease is a common chronic disorder that affects the and is believed to develop as a result of an aberrant to intestinal microbes in a genetically susceptible host. Over the last decade, high levels of adherent invasive E. coli (AIEC) have been reported. One study isolated the bacteria in 36% of Crohn's sufferers compared to just 6% of controls.

Since Crohn's disease is a clinical subtype of (IBD) and others have reported successful treatment of IBC with the probiotic E. coli Nissle 1917 (EcN), the researchers investigated the impact EcN might have on an already established infection with AIEC in mimicking those found in the lining of the intestines.

They found that treatment with EcN not only helped prevent the AIEC reference strain LF82 from invading the cells and establishing infection, it also appears to modulate production of immune proteins that cause inflammation.

"This study is the first to our knowledge to show that EcN can reduce some of the negative effects associated with the strain LF82 in an already established AIEC infection and emphasizes the potential of EcN in IBD treatment. In particular the use of this probiotic could be of interest in CD patients harboring pathogenic AIEC," write the researchers.

Explore further: Fighting bacteria—with viruses

Provided by American Society for Microbiology

not rated yet
add to favorites email to friend print save as pdf

Related Stories

Promising probiotic treatment for inflammatory bowel disease

Jan 20, 2010

Bacteria that produce compounds to reduce inflammation and strengthen host defences could be used to treat inflammatory bowel disease (IBD). Such probiotic microbes could be the most successful treatment for IBD to date, ...

Probiotic identified to treat ulcers

Feb 24, 2011

Researchers from Spain have identified a strain of probiotic bacteria that may be useful in treating ulcers caused by Helicobacter pylori. They report their findings in the February 2011 issue of the journal Applied and Envir ...

Banana plantain fibers could treat Crohn's disease

Aug 25, 2010

Crohn's is a condition that affects one in 800 people in the UK and causes chronic intestinal inflammation, leading to pain, bleeding and diarrhoea. Researchers are working with biotechnology company, Provexis, to test a ...

Protein found to be key in protecting the gut from infection

Feb 17, 2010

A signaling protein that is key in orchestrating the body's overall immune response has an important localized role in fighting bacterial infection and inflammation in the intestinal tract, according to a study by UC San ...

Recommended for you

Fighting bacteria—with viruses

17 hours ago

Research published today in PLOS Pathogens reveals how viruses called bacteriophages destroy the bacterium Clostridium difficile (C. diff), which is becoming a serious problem in hospitals and healthcare institutes, due to its re ...

Atomic structure of key muscle component revealed

18 hours ago

Actin is the most abundant protein in the body, and when you look more closely at its fundamental role in life, it's easy to see why. It is the basis of most movement in the body, and all cells and components ...

Brand new technology detects probiotic organisms in food

Jul 23, 2014

In the food industr, ity is very important to ensure the quality and safety of products consumed by the population to improve their properties and reduce foodborne illness. Therefore, a team of Mexican researchers ...

Protein evolution follows a modular principle

Jul 23, 2014

Proteins impart shape and stability to cells, drive metabolic processes and transmit signals. To perform these manifold tasks, they fold into complex three-dimensional shapes. Scientists at the Max Planck ...

Report on viruses looks beyond disease

Jul 22, 2014

In contrast to their negative reputation as disease causing agents, some viruses can perform crucial biological and evolutionary functions that help to shape the world we live in today, according to a new report by the American ...

User comments : 1

Adjust slider to filter visible comments by rank

Display comments: newest first

6_6
not rated yet Mar 31, 2011
it works. probiotics do wonders along with psyllium also (wrongly assumed to be for only for constipation)