Mother's obesity may lead to infertility in the next generation

Mar 23, 2011

Levels of the hormone ghrelin are low in obese women and a recent study accepted for publication in Endocrinology, a publication of The Endocrine Society, reports that mice whose mothers had low ghrelin levels were less fertile due to a defect in implantation.

Hormones involved in energy balance and , such as ghrelin, have been shown to regulate reproductive function in animals and humans. However ghrelin's role in reproductive tract development remains unclear. The current study examined the effect of ghrelin deficiency on the developmental programming of female fertility.

"While our study involved mice, we believe our findings have significant implications for women," said Hugh Taylor, MD, of the Yale University School of Medicine in New Haven, Conn. and lead author of the study. "Our results suggest that low ghrelin levels could program the development of the in the female children of . These women may then be less fertile as adults."

In this study, researchers observed that female mice born of mice with ghrelin deficiency had diminished fertility and produced smaller litters than mice born of mice with normal ghrelin levels. Mice exposed to ghrelin deficiency in-utero demonstrated alterations in uterine which lead to impaired embryo implantation and consequently low fertility.

Explore further: Sporting events should ditch nutritional supps and sports drinks sponsorship

More information: The article, "Maternal Ghrelin Deficiency Compromises Reproduction in Female Progeny through Altered Uterine Developmental Programming," appears in the April 2011 issue of Endocrinology.

add to favorites email to friend print save as pdf

Related Stories

Hormone ghrelin can boost resistance to Parkinson's disease

Nov 25, 2009

Ghrelin, a hormone produced in the stomach, may be used to boost resistance to, or slow, the development of Parkinson's disease, Yale School of Medicine researchers report in a study published in a recent issue of the Journal of ...

Fatty foods fire up hunger hormone

Jun 06, 2009

New research led by the University of Cincinnati (UC) suggests that the hunger hormone ghrelin is activated by fats from the foods we eat—not those made in the body—in order to optimize nutrient metabolism and promote ...

Gut hormone makes food look even yummier

May 06, 2008

A gut hormone that causes people to eat more does so by making food appear more desirable, suggests a new report in the May issue of Cell Metabolism, a publication of Cell Press. In a brain imaging study of individuals, the re ...

Recommended for you

We drink more alcohol on gym days

9 hours ago

A new Northwestern Medicine study finds that on days when people exercise more—typically Thursdays to Sundays—they drink more alcohol, too.

Obesity and stress pack a double hit for health

15 hours ago

If you're overweight, you may be at greater risk for stress-related diseases like type 2 diabetes, cardiovascular disease and cancer, according to a new study by Brandeis University.

User comments : 1

Adjust slider to filter visible comments by rank

Display comments: newest first

stevesmith
not rated yet Mar 24, 2011
Hi,
Thanks for posting this article..Really very helpful information posted here.Obesity can increase the risk of Heart Disease, Stroke, Type 2 Diabetes, Cancers, Liver Disease,Breathing Problems.

Raymeds.com