Research suggests HIV-infected patients at higher risk for bone fractures

Mar 11, 2011

Low bone mineral density in HIV-infected patients is common and raises concerns about increased risks of fracture. Although there have been several studies regarding bone mineral density, there have been few data on rates of fracture in this population. A new study published in Clinical Infectious Diseases and available online examined differences in the rates of bone fractures between HIV-infected patients and the general population and found higher rates of fracture among HIV patients.

A total of 5,826 HIV-infected patients were analyzed from 2000 to 2008 in the study. The researchers were able to compare rates with persons in the general U.S. population for the period from 2000 to 2006 and observed that annual fracture rates among HIV-infected patients were between 1.98 and 3.69 times greater.

"We confirmed that several established risk factors for fracture, such as age, substance abuse, co-infection, and diabetes, were associated with fractures among the HIV-infected patients," said study author Benjamin Young, MD, PhD, of the Rocky Mountain Center for AIDS Research, Education, and Services in Denver. "This study also highlights for the first time a potential association between fracture risk and CD4 cell count. The optimal clinical management of bone health in HIV-infected individuals is not well defined and remains controversial."

Dr. Young added, "We believe our data support the need to develop guidelines that address screening for and correcting reversible causes of low and fall risk and that these activities should be incorporated into the routine care of HIV-infected patients."

Explore further: Indiana HIV outbreak, hepatitis C epidemic sparks US alert

More information: http://www.oxfordjournals.org/our_journals/cid/ciq242.pdf

Related Stories

HIV patients at greater risk for bone fractures

Aug 28, 2008

HIV-infected patients have a higher prevalence of fractures than non HIV-infected patients, across both genders and critical fracture sites according to a new study accepted for publication in The Endocrine Society's Journal of ...

Retinoid use not associated with fracture risk

May 17, 2010

Individuals treated for acne, psoriasis or another skin condition with vitamin A analogues (retinoids) do not appear to be at increased risk of fracture, according to a report in the May issue of Archives of Dermatology.

Recommended for you

Indiana HIV outbreak, hepatitis C epidemic sparks US alert

Apr 24, 2015

Federal health officials helping to contain an HIV outbreak in Indiana state issued an alert to health departments across the U.S. on Friday, urging them to take steps to identify and track HIV and hepatitis C cases in an ...

Why are HIV survival rates lower in the Deep South than the rest of the US?

Apr 22, 2015

The Deep South region has become the epicenter of the US HIV epidemic. Despite having only 28% of the total US population, nine states in the Deep South account for nearly 40% of national HIV diagnoses. This region has the highest HIV diagnosis rates and the highest number of people living with HIV of any ...

A bad buzz: Men with HIV need fewer drinks to feel effects

Apr 20, 2015

Researchers at Yale and the VA Pittsburgh Healthcare System compared the number of drinks that men with HIV infection, versus those without it, needed to get a buzz. They found that HIV-infected men were more sensitive to ...

User comments : 0

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.