Beating cancer with immune cells

Mar 04, 2011

The fight against cancer has received a significant boost with a medical breakthrough by researchers at The Australian National University.

Professor Chris Parish and Dr. Ben Quah from The John Curtin School of Medical Research have discovered that responding to a foreign substance, or pathogen, are able to rapidly transfer their ability to recognise the invader to other immune cells.

Professor Parish said that harnessing this process may lead to new ways to treat cancerous tumours as well as strengthen immunity in patients with weaker immune systems.

“Our discovery revolutionises our understanding of how the immune system works,” said Professor Parish.

“It indicates that there is much more communication and sharing of information between cells of the immune system than was previously thought.

“These findings can potentially be harnessed to expand immunity against and . In the case of cancer the number of immune cells in a patient that can recognise and eliminate the cancer could be dramatically expanded.

“Another obvious application of our discovery is in patients with decreased immunity. Again this form of cell to cell communication could be used to expand the number of immune cells in these individuals that can combat opportunistic infections,” he said.

Professor Parish added that he started research on this phenomenon in the immune system over 10 years ago.

“Although at the time we regarded the work as extremely heretical,” said Professor Parish.

“It took many years for us to obtain sufficient data to convince ourselves that the phenomenon was genuine. Now there is no doubt that the sharing of information and abilities between cells of the is genuine.

“Understanding when, why and how it occurs and whether it can be harnessed to combat cancer and infections is the challenge for the future,” he said.

The researchers’ innovative work on cells has landed them the inaugural Marshall and Warren Award from the National Health and Medical Research Council (NHMRC).

Named after Physiology and Medicine Nobel prize-winners Barry Marshall and Robin Warren, the award aims to help Australian scientists respond to the nation’s future health needs.

Professor Parish’s and Dr. Quah’s breakthrough was selected as the most potentially transformative research from over 3,600 project grant applications to the NHMRC. The researchers will now receive $521,706 over three years to continue their work.

Professor Parish and Dr. Quah were presented with their award in a ceremony at University House, ANU, overnight.

Explore further: Survival differences seen for advanced-stage laryngeal cancer

Provided by Australian National University

5 /5 (3 votes)
add to favorites email to friend print save as pdf

Related Stories

Study: New way to control inflammation

Oct 03, 2006

U.S. researchers say they've discovered a new way to control or terminate potentially harmful immune responses that produce inflammation.

Scientists discover how to improve immune response to cancer

Apr 26, 2009

A team of scientists at The Campbell Family Institute for Breast Cancer Research (CFIBCR) at Princess Margaret Hospital and international collaborators have discovered how to trigger an improved immune response to cancer ...

Recommended for you

Gene test aids cancer profile

18 hours ago

The first round of chemotherapy did little to suppress Ron Bose's leukemia. The second round, with 10 times the dose, knocked the proliferating blast cells down, but only by half.

User comments : 0

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.