Scientists discover cell of origin for childhood muscle cancer

Feb 15, 2011

Researchers at Oregon Health & Science University Doernbecher Children's Hospital have defined the cell of origin for a kind of cancer called sarcoma. In a study published today as the Featured Article in the journal Cancer Cell, they report that childhood and adult sarcomas are linked in their biology, mutations and the cells from which these tumors first start. These findings may lead to non-chemotherapy medicines that can inhibit "molecular targets" such as growth factor receptors, thereby stopping or eradicating the disease.

Childhood muscle cancer, or rhabdomyosarcoma, is a condition that when spread throughout the body has a low survival rate — just 20 percent to 40 percent. In adults with soft tissue sarcomas, survival can be even lower. Now, for the first time, the researchers have shown from where these tumors arise and what drives them to grow and spread.

"A commonly held belief is that cancers should be cut out, burned out or killed. There is a fourth option — to have cancer cells choose to become normal cells, in this case muscle cells," said Charles Keller, M.D., principal investigator of the study, leader of Pediatric Cancer Biology Program in the Papé Family Pediatric Research Institute at OHSU Doernbecher Children's Hospital, and a member of the OHSU Knight Cancer Institute and the Oregon Stem Cell Center at OHSU.

"At least for a subset of patients, possibly the ones with hereditary cancer, one approach suggested by our research might be to administer drugs that muscle cancers to convert into non-cancerous muscle fibers. This is a minority opinion, but one held by a small group of careful scientists throughout the United States and abroad," said Keller.

The survival rate for childhood muscle cancer that has spread has remained unchanged for more than 40 years. It has reached the point that increasing the intensity of chemotherapy, radiation or surgery is no longer having any improved effect, Keller explained. He and colleagues have taken a novel approach in the laboratory as well as in new clinical trials, using non-chemotherapy medicines to inhibit "molecular targets" such as receptors.

Suman Malempati, M.D., assistant professor of pediatrics (hematology/oncology) and director of the Oncology Developmental Therapeutics Program at OHSU Doernbecher Children's Hospital, is the lead on a national clinical trial of one such growth factor inhibitor. This is the Children's Oncology Group's first trial incorporating a molecularly targeted drug into a clinical trial for childhood muscle cancer and was funded by CureSearch for Children's Cancer, a nationwide network of hospitals, doctors and leading scientists that develop new treatments for childhood cancer.

This type of therapy tailored to a cancer's mutation was first pioneered at OHSU by Brian J. Druker, M.D., director of the OHSU Knight Cancer Institute and recipient of the 2009 Lasker~DeBakey Clinical Medical Research Award, commonly referred to as America's Nobel Prize. Druker and colleagues developed Gleevec, the first genetically targeted, non-chemotherapy pill for chronic myeloid leukemia (CML) that left healthy cells unharmed and converted this fatal into a manageable chronic condition.

Explore further: New study demonstrates advances in creating treatment for common childhood blood cancer

add to favorites email to friend print save as pdf

Related Stories

OHSU discovery may lead to early cancer detection

May 22, 2008

This week researchers in the Oregon Health & Science University (OHSU) Oregon Stem Cell Center and the OHSU Digestive Health Center are shining a new ray of hope on patients with pancreatic cancer. They’ve developed new ...

Novel cancer drug reduces neuroblastoma growth by 75 percent

Apr 23, 2009

Researchers from the Children's Cancer Hospital at The University of Texas M. D. Anderson Cancer Center have found a new drug that restricts the growth of neuroblastoma, a childhood brain cancer. The pre-clinical study was ...

Recommended for you

ACG: Recent increase in incidence of young-onset CRC

3 hours ago

(HealthDay)—The incidence of young-onset colorectal cancer (CRC) is increasing, and the disease is more aggressive pathologically. These findings are being presented at the annual meeting of the American ...

User comments : 0