Scientists grow blood vessels for human surgery

Feb 02, 2011
This is a 6 mm-diameter decellularized human bioengineered vein before implant. Credit: Image courtesy of Science/AAAS

Scientists can grow blood vessels in a lab for use in coronary bypass or dialysis, a promising alternative to harvesting from the patient, said a study published on Wednesday.

The process involves taking smooth muscle cells from a human cadaver and grafting them onto tubes made of the material used in making dissolvable stitches, called polyglycolic acid.

Within eight to 10 weeks, the tubes degrade and a "fully formed vascular graft" remains, said the research by scientists from Duke University, East Carolina University and Yale University.

The veins have been tested in baboons and dogs. They were not rejected by the animals' bodies and functioned well for six months, said the study, published in the journal .

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In this newly published research by scientists at Humacyte Inc., Duke, East Carolina and Yale universities, bioengineered veins are generated by culturing human cells in a bioreactor to form a robust tissue. Cells are removed from the tissue, and the bioengineered veins can be stored for up to 12 months in refrigeration until time of patient need. These bioengineered veins may be developed in large diameter for use in vascular access in kidney dialysis or small diameter for use in bypass surgery. Bioengineered veins have demonstrated excellent blood flow and resistance to clotting. Credit: Video courtesy of Science/AAAS

The bio-engineered vessels could also be stored in saline solution for up to a year, suggesting that one day surgeons could pluck a vein "off the shelf" for use in a sick patient, the study said.

"These can be made ahead of time and then are ready to go whenever they are needed," the paper said.

Clinical trials in humans are expected to begin soon, according to a spokeswoman from Humacyte, a company based in North Carolina that also contributed to the study and funded the research.

In this research, bioengineered veins are generated by culturing human cells in a bioreactor and removing cells after vein growth. Bioengineered veins may be developed in large diameter for use in vascular access in kidney dialysis or in small diameter for use in bypass surgery and stored for up to 12 months until time of patient need. Credit: Image Courtesy of Science/AAAS

"Currently, grafting using the patient's own veins remains the gold standard," said co-author Alan Kypson of the Brody School of Medicine at East Carolina University.

"But, harvesting a vein from the patient's leg can lead to complications, and for patients who don't have suitable veins, the bio-engineered veins could serve as an important new way to provide a coronary bypass."

The engineered vessels also have "decreased potential for infection, obstruction or clotting," the study noted.

Shannon Dahl, senior director of Scientific Operations at Humacyte, said veins can be made in a variety of sizes for use in different operations.

"We can make the bio-engineered veins in large and small diameter which means they can be used for procedures ranging from hemodialysis for patients with kidney failure and for coronary by-pass," she said.

The National Kidney Foundation says that 320,000 patients require dialysis, and "more than half of dialysis patients lack the healthy necessary and must undergo an arteriovenous graft (AV graft) placement" for the procedure.

Around 400,000 procedures are performed annually in the United States, according to the American Heart Association.

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trekgeek1
not rated yet Feb 02, 2011
They were not rejected by the animals' bodies and functioned well for six months


Then what? Don't get me wrong, this is a great advancement. However, they kind of left us hanging with that sentence.
krierpat
not rated yet Feb 02, 2011
"functioned well for six months." Does this mean they need to be replaced after six months. Does it mean that the study was published only after six months and they don't know what happens after that?
John_balls
5 / 5 (4) Feb 02, 2011
I'm guessing that they are still monitoring these animals and up to this point(6 months) they are still going strong.
DamienS
not rated yet Feb 03, 2011
I'm guessing that they are still monitoring these animals and up to this point(6 months) they are still going strong.

Yes, that's likely it or the study was only funded for that amount of time. That's often the case with studies. If the results are positive, then other, broader studies or trials will be started.

But yes, that kind of wording often leads to confusion when reported in pop media.
Jonathan_Q
not rated yet Feb 09, 2011
Do you have to use human cadavers what about using pigs and/or cows there would be plenty of leftover "parts" to reuse. We could raise some pigs with some genetic likeness to humans we could use.