Hashimoto's thyroiditis can affect quality of life

Feb 25, 2011
Thyroid, the official journal of the American Thyroid Association (www.thyroid.org) is an authoritative peer-reviewed journal published monthly in print and online. The Journal publishes original articles and timely reviews that reflect the rapidly advancing changes in our understanding of thyroid physiology and pathology, from the molecular biology of the cell to clinical management of thyroid disorders. Complete tables of content and a free sample issue may be viewed online at www.liebertpub.com/thy. Credit: © Mary Ann Liebert, Inc. publishers

Hashimoto's thyroiditis (HT), an inflammatory disorder of the thyroid, is the most common cause of hypothyroidism, but a study has suggested that even when thyroid function is normal, HT may increase symptoms and decrease quality of life, as described in an article in Thyroid, a peer-reviewed journal published by Mary Ann Liebert, Inc. Thyroid is the Official Journal of the American Thyroid Association (ATA).

Hashimoto's thyroiditis most commonly affects middle-aged women and is associated with an array of symptoms that include , dry hair, chronic irritability, difficulty concentrating, constipation, and chronic nervousness. Affected patients tend to report decreased quality of life. HT is an autoimmune disorder in which the body produces an antibody that attacks the resulting in inflammation, and often decreased ().

Johannes Ott and colleagues from Kaiserin Elisabeth Spital and Medical University of Vienna, Austria, report that women with higher levels of anti-thyroid antibody had a significantly higher number of symptoms, even though their levels of thyroid-stimulating hormone (TSH)—a measure of thyroid function—did not differ from TSH levels measured in women with lower antibody levels. In the article, "Hashimoto's Thyroiditis Affects Symptom Load and Quality of Life Unrelated to Hypothyroidism: A Prospective Case-Control Study in Women Undergoing Thyroidectomy for Benign Goiter," the authors conclude that hypothyroidism is only one factor contributing to HT symptoms.

"This study raises important clinical issues. Although the authors did not study thyroid hormone treatment for Hashimoto's thyroiditis, it raises the possibility that optimal doses of thyroid hormone will not completely ameliorate all symptoms. Further studies are required to confirm the findings of Ott et al. and to determine if patients with hypothyroidism due to Hashimoto's thyroiditis still have residual symptoms despite achieving an ideal biochemical response to thyroid hormone replacement therapy," says Charles H. Emerson, MD, Editor-in-Chief of Thyroid and Professor Emeritus of Medicine at the University of Massachusetts School of Medicine, in Worcester.

Explore further: Discovery of genes that predispose a severe form of COPD

More information: The article is available free online at www.liebertpub.com/thy

Provided by Mary Ann Liebert, Inc.

4.5 /5 (2 votes)
add to favorites email to friend print save as pdf

Related Stories

Pediatric obesity may alter thyroid function and structure

Dec 03, 2008

In addition to its strong associations with hypertension, cardiovascular disease, and diabetes, pediatric obesity may induce alterations in thyroid function and structure, according to a new study accepted for publication ...

Low thyroid function common in chronic kidney disease

Jun 11, 2008

Many patients with chronic kidney disease (CKD) have mild reductions in thyroid function, or subclinical hypothyroidism—a condition that becomes more common as kidney function declines, according to a study in the September ...

Pre-eclampsia linked to thyroid problems

Nov 18, 2009

Women who develop pre-eclampsia during pregnancy are more likely than other women to have reduced thyroid function (hypothyroidism), finds a study published in BMJ today. It may also put women at a greater risk of thyroi ...

Recommended for you

Liberia holds Senate vote amid Ebola fears

1 hour ago

Health workers manned polling stations across Liberia on Saturday as voters cast their ballots in a twice-delayed Senate vote that has been criticized for its potential to spread the deadly Ebola disease.

Evidence-based recs issued for systemic care in psoriasis

21 hours ago

(HealthDay)—For appropriately selected patients with psoriasis, combining biologics with other systemic treatments, including phototherapy, oral medications, or other biologic, may result in greater efficacy ...

Bacteria in caramel apples kills at least four in US

21 hours ago

A listeria outbreak believed to originate from commercially packaged caramel apples has killed at least four people in the United States and sickened 28 people since November, officials said Friday.

Steroid-based treatment may answer needs of pediatric EoE patients

22 hours ago

A new formulation of oral budesonide suspension, a steroid-based treatment, is safe and effective in treating pediatric patients with eosinophilic esophagitis (EoE), according to a new study in Clinical Gastroenterology and Hepatology, the official clinical practice journal ...

Discovery of genes that predispose a severe form of COPD

Dec 19, 2014

A study by Ramcés Falfán-Valencia, researcher at the National Institute of Respiratory Diseases (INER), found that the mestizo Mexican population has a number of variations in certain genes that predispose ...

User comments : 1

Adjust slider to filter visible comments by rank

Display comments: newest first

drahaskell
not rated yet Feb 26, 2011
One statement in this article, 'an antibody that attacks the thyroid gland resulting in inflammation' is a very common misunderstanding among physicians.

The origin of Hashimoto's is thyroid inflammation. This is why such a high percentage of people with Subclinical Hypothyroidism develop Hashimoto's. It's time for us physicians to understand that to treat Hashimoto's is by reducing thyroid inflammation. This may mean prescribing thyroid hormones to reduce TSH but there are other means which are exposed by a number of medical journals from around the world.

We have to start thinking about cause and not just trying to adjust levels of thyroid hormones.

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.