Drug to fight tumors also fights the flu and possibly other viruses

Feb 28, 2011

Ever get a flu shot and still get the flu? If so, there's new hope for flu-free winters in the years to come thanks to a new discovery by researchers who found that a drug called DMXAA, originally developed as anti-tumor agent, enhances the ability of flu vaccines to ward off this deadly virus. A new research report appearing in the March 2011 issue of the Journal of Leukocyte Biology suggests that DMXAA could assist flu vaccines by causing the body to produce its own antiviral proteins, called interferons, which interfere with the virus's ability to spread. In addition, DMXAA may be a useful antiviral therapy to treat newly emerging strains of the flu for which a vaccine has not be developed.

"We are hopeful that DMXAA or similar agents can be used ultimately to blunt the impact of yearly influenza outbreaks, and perhaps, for other virus infections as well," said Stefanie Vogel, Ph.D., co-author of the study and Professor of Microbiology and Immunology at the University of Maryland, School of Medicine in Baltimore.

To make this discovery, Vogel and colleagues infected mice with a mouse-adapted . When given DMXAA three hours before or after infection and then two days later, the infection was significantly less severe. In addition, they found that DMXAA protected cells from strains that are resistant to , one of the most advanced anti-flu drugs on the market. These discoveries suggest that DMXAA could potentially enhance the efficacy of current flu treatments and vaccines, and perhaps treat other viruses or bacteria. To be sure that DMXAA led to increased production of interferons, the researchers also tested it in mice that lacked a gene needed to produce interferon, and found that these mice received no benefit from DMXAA.

"H1N1 was a wake-up call that the flu remains a very serious disease, regardless of how "common" we may think it is," said John Wherry, Ph.D., Deputy Editor of the . "Every year this virus mutates, and history has shown us that new, very dangerous strains of this virus will continue to emerge. New drugs like this one that can combat this virus—especially drugs that are effective against newly emerging strains—may prove to be lifesaving for millions of people around the world."

Explore further: Seniors successfully withdraw from meds

More information: Kari Ann Shirey, Quan M. Nhu, Kevin C. Yim, Zachary J. Roberts, John R. Teijaro, Donna L. Farber, Jorge C. Blanco, and Stefanie N. Vogel
The anti-tumor agent, 5,6-dimethylxanthenone-4-acetic acid (DMXAA), induces IFN-β-mediated antiviral activity in vitro and in vivo
J Leukoc Biol. March 2011 89:351-357; doi:10.1189/jlb.0410216

add to favorites email to friend print save as pdf

Related Stories

Bird flu vaccine protects people and pets

Oct 20, 2008

A single vaccine could be used to protect chickens, cats and humans against deadly flu pandemics, according to an article published in the November issue of the Journal of General Virology. The vaccine protects birds and ma ...

Unusual flu vaccine is developed

Jun 14, 2006

U.S. scientists have used reverse genetics to develop an influenza virus with two key proteins on its surface derived from the H5N1 avian virus strain.

Recommended for you

Seniors successfully withdraw from meds

Sep 19, 2014

Elderly people have proved receptive to being de-prescribed medications, as part of a trial aimed at assessing the feasibility of withdrawal of medications among older people.

Flu vaccine for expectant moms a top priority

Sep 18, 2014

Only about half of all pregnant women in the U.S. get a flu shot each season, leaving thousands of moms-to-be and their babies at increased risk of serious illness.

Experts want restrictions on testosterone drug use (Update)

Sep 17, 2014

Federal health experts said Wednesday there is little evidence that testosterone-boosting drugs are effective for treating common signs of aging in men and that their use should be narrowed to exclude millions of Americans ...

User comments : 0