Transforming skin cells into cartilage

Jan 10, 2011

In this paper, Noriyuki Tsumaki and his team at the Osaka University Graduate School of Medicine, used fibroblasts isolated from adult mouse skin, and expressed proteins used to induce pluripotency along with a factor that promotes a chondrocyte fate. The resulting cells resembled chondrocytes and produced cartilage when injected into mice. This may be an important step toward a therapy that will allow the repair of cartilage injury using a patient's own skin cells.

Hyaline cartilage, composed primarily of chondrocytes in an extensive extracellular matrix, makes up the embryonic skeleton and persists in adults at the ends of bones, where it provides shock absorption and lubrication of joints.

Hyaline cartilage injury often results in the formation of the scar tissue fibrocartilage or even new bone formation leading to growth impairment or . However, of cartilage might be possible if researchers can develop a method to generate new chondrocytes.

In this paper, Noriyuki Tsumaki and his team at the Osaka University Graduate School of Medicine, used fibroblasts isolated from adult mouse skin, and expressed proteins that have previously been used to induce pluripotency along with a factor that promotes a chondrocyte fate.

This produced cells with traits that resembled chondrocytes and produced cartilage when injected into mice. The researchers believe this may be an important step toward a therapy that will allow th
e repair of cartilage injury using a patient’s own .

Explore further: Letrozole is a promising new treatment of male infertility, researcher says

More information: View this article at: www.jci.org/articles/view/4460… 631d5aff983c237cf1dc

Provided by Journal of Clinical Investigation

5 /5 (2 votes)
add to favorites email to friend print save as pdf

Related Stories

Scientists progress in successful tissue engineering

Mar 23, 2007

Tissue engineering is a relatively new field of basic and clinical science that is concerned, in part, with creating tissues that can augment or replace injured, defective, or diseased body parts.

How movement lubricates bone joints

Dec 05, 2006

Taking a cue from machines that gently flex patients’ knees to help them recover faster from joint surgery, bioengineering researchers at UC San Diego have shown that sliding forces applied to cartilage surfaces ...

Bone formation from embryonic stem cells

Oct 22, 2009

Jojanneke Jukes of the University of Twente, The Netherlands, has succeeded in growing bone tissue with the help of embryonic stem cells for the first time.

Recommended for you

Radical vaccine design effective against herpes viruses

1 hour ago

Herpes simplex virus infections are an enormous global health problem and there is currently no viable vaccine. For nearly three decades, immunologists' efforts to develop a herpes vaccine have centered on ...

Popular antioxidant likely ineffective, study finds

10 hours ago

The popular dietary supplement ubiquinone, also known as Coenzyme Q10, is widely believed to function as an antioxidant, protecting cells against damage from free radicals. But a new study by scientists at McGill University ...

New findings on 'key players' in brain inflammation

11 hours ago

Inflammation is the immune system's natural reaction to an 'aggressor' in the body or an injury, but if the inflammatory response is too strong it becomes harmful. For example, inflammation in the brain occurs ...

Gut microbial mix relates to stages of blood sugar control

Mar 05, 2015

The composition of intestinal bacteria and other micro-organisms—called the gut microbiota—changes over time in unhealthy ways in black men who are prediabetic, a new study finds. The results will be presented Friday ...

User comments : 0

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.