Researcher studies rare type of breast cancer

Jan 26, 2011 by Ann Manser
This image shows an inflammatory breast cancer tumor that van Golen's research group grew in the lab using a novel material that mimics the lymphatic system.

For University of Delaware researcher Kenneth van Golen, the advances made in recent years in treating breast cancer have a bittersweet element.

The disease on which he focuses -- inflammatory breast cancer, or IBC -- is relatively rare, far less studied and much more deadly than the common form of cancer that is the subject of a great deal of scientific research, fundraising drives, media attention and public education campaigns. All those efforts have paid off in earlier detection and more effective treatment for common breast cancer, which affects the largest number of women, and van Golen wholeheartedly applauds the progress that has been made.

At the same time, the associate professor of biological sciences is concerned that less-common breast cancers are not receiving the same kinds of attention. IBC is the opposite of common breast cancer in many ways, he says, including the success of treatment: While common breast cancer now has an 80 percent survival rate, only about 20 percent of IBC patients live more than 10 years after diagnosis.

“I started working with inflammatory breast cancer in 1996, and for a long time, it was a disease that was relatively ignored by researchers,” van Golen says. “Until about 2003, people argued over whether it was even a distinct disease, and the first international conference on it wasn't held until 2008.”

Now, he says, conferences are held regularly, and the one slated for 2012 is to be hosted by UD. Still, he estimates that his lab is one of just one or two dozen worldwide that are devoted to IBC research. And, at the recent San Antonio Breast Cancer Conference, the largest such gathering in the world, he says that of some 2,000 posters on view, only six were on the topic of IBC, with three of those six presented by his own students.

The disease is not only studied infrequently, but it also is often misdiagnosed at first, causing patients and physicians to lose valuable time in beginning to treat the aggressive cancer. Because it accounts for just 1-9 percent of breast cancer cases, and because it resembles an infection rather than a typical cancer, many doctors “haven't seen this disease since medical school,” van Golen says, and try to treat it with antibiotics.

“It has none of the hallmarks of a typical cancer, either in the way it presents or in the types of treatment that are effective,” he says. “When I first encountered this disease, I was told by an oncologist: This is . It doesn't follow any of the rules.”

Among the differences from common breast cancer, IBC doesn't generally have tumors that can be felt in an exam or detected by a mammogram; it causes redness, soreness and skin changes that make it appear to be an infection; it affects younger women, some as young as teenagers; and it spreads very rapidly through the lymphatic system. Because IBC is systemic, and because it often has progressed before diagnosis, treatment is aggressive and extensive, including surgery, chemotherapy and intensive radiation therapy.

Calling the current treatments harsh and extremely difficult for patients, van Golen says, “Our approach is to figure out molecularly what's going on with this disease and then target specific pathways” to combat it. His lab has collaborated with one in Belgium, which has established the distinctive “molecular signature” of IBC.

His lab is conducting pre-clinical trials with drugs currently used for other types of cancers, including a type of leukemia, and he hopes to partner with cancer treatment centers in the region to conduct clinical trials with patients by 2014.

Meanwhile, the key to fighting IBC is education, van Golen believes. He says that both physicians and women need to recognize the earliest symptoms of the disease and test for it so that treatment can begin immediately and have the best chances of success.

“The community involved with inflammatory is very small, so you're immediately not just a researcher but also an advocate,” van Golen says. “Education is the key with this disease. Education will save lives.”

Explore further: New cancer drug target involving lipid chemical messengers

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