MRI: An accurate method to evaluate iron overload

Jan 31, 2011

A research team from Iran investigated the accuracy of T2*-weighted magnetic resonance imaging (MRI T2*) in the evaluation of iron overload in beta-thalassemia major patients. The study showed that MRI T2* is a non-invasive, safe and reliable method for detecting iron load in patients with iron overload.

Iron overload is a common and serious problem in thalassemic major patients. As iron accumulation is toxic in the body's tissues, accurate estimation of iron stores is of great importance in these patients to prevent iron overload by an appropriate iron chelating therapy. is the gold standard for evaluating iron stores but it is an invasive method which is not easily repeatable in patients. Introduction of other more applicable methods seems to be necessary.

A research article published on January 28, 2011 in the addresses this question. The authors reported their experience of using T2*-weighted (MRI T2*) for determining iron overload in beta-thalassemic patients in Iran. They compared liver MRI T2* results in thalassemic patients with their liver biopsy results to determine if it is possible to substitute MRI T2* to assess iron overload in these patients.

The results indicated that the serum ferritin level is not a reliable method for estimating the level of in thalassemic patients. MRI T2* is a more accurate and non-invasive method which they recommend for measurement of iron load in these patients.

Explore further: Common food supplement fights degenerative brain disorders

More information: Zamani F, Razmjou S, Akhlaghpoor S, Eslami SM, Azarkeivan A, Amiri A. T2* magnetic resonance imaging of the liver in thalassemic patients in Iran. World J Gastroenterol 2011;17(4): 522-525. www.wjgnet.com/1007-9327/full/v17/i4/522.htm

add to favorites email to friend print save as pdf

Related Stories

Scientists discover novel way to remove iron from ferritin

Nov 02, 2007

A new study led by Children's Hospital Oakland Research Institute senior scientist, Elizabeth Theil, Ph.D., is the first to suggest that a small protein or heptapeptide (seven amino acids wrapped into one unit) could be used ...

Europe's most common genetic disease is a liver disorder

Feb 06, 2008

Much less widely known than the dangerous consequences of iron deficiencies is the fact that too much iron can also cause problems. The exact origin of the genetic iron overload disorder hereditary hemochromatosis (HH) has ...

New Nanoparticle Structure Boosts Magnetic Properties

Dec 19, 2005

Magnetic nanoparticles have shown promise as contrast-enhancing agents for improving cancer detection using magnetic resonance imaging (MRI), as miniaturized heaters capable of killing malignant cells, and as targeted drug ...

Recommended for you

How healthy are you for your age?

4 hours ago

On May 22, JoVE will publish details of a technique to measure the health of human genetic material in relation to a patient's age. The method is demonstrated by the laboratory of Dr. Gil Atzmon at New York's Albert Einste ...

User comments : 0

More news stories