Preventing GVHD by protecting gut stem cells

Jan 31, 2011

A protein that protects stem cells in the gut relieves a potentially lethal complication of bone marrow transplantation in mice, according to a study published online on January 31 in the Journal of Experimental Medicine.

Bone marrow transplantation can cure diseases such as leukemia but it can also lead to a potentially fatal complication known as graft-versus-host disease (GVHD).

A group led by Takanori Teshima at Kyushu University in Japan found that mice treated with a protein called R-spondin1 developed less severe GVHD after bone marrow transplantation.

R-spondin worked by protecting intestinal , which help to regenerate damaged tissues and thus dampen .

Whether R-spondin1 is therapeutic for human bone marrow transplant patients remains to be explored.

Explore further: New compounds protect nervous system from the structural damage of MS

More information: Takashima, S., et al. 2011. J. Exp. Med. doi:10.1084/jem.20101559

add to favorites email to friend print save as pdf

Related Stories

Molecule dictates how stem cells travel

Jan 14, 2006

U.S. researchers have defined a molecule that dictates how blood stem cells travel to the bone marrow and establish blood and immune cell production.

Blood test could improve graft-versus-host disease treatment

Jan 08, 2010

University of Michigan researchers have identified the first biomarker of graft-versus-host disease of the skin. The discovery makes possible a simple blood test that should solve a treatment dilemma facing doctors with patients ...

Recommended for you

Mystery of the reverse-wired eyeball solved

Feb 27, 2015

From a practical standpoint, the wiring of the human eye - a product of our evolutionary baggage - doesn't make a lot of sense. In vertebrates, photoreceptors are located behind the neurons in the back of the eye - resulting ...

Neurons controlling appetite made from skin cells

Feb 27, 2015

Researchers have for the first time successfully converted adult human skin cells into neurons of the type that regulate appetite, providing a patient-specific model for studying the neurophysiology of weight ...

Quality control for adult stem cell treatment

Feb 27, 2015

A team of European researchers has devised a strategy to ensure that adult epidermal stem cells are safe before they are used as treatments for patients. The approach involves a clonal strategy where stem cells are collected ...

User comments : 0

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.