Restoring emotional memory in a rat model of major depressive disorder

Jan 18, 2011

Deficits in emotional memory processing associated with major depressive disorder (MDD) are shown to be reversible by distinct antidepressants, shows researchers at Karolinska Institutet in an animal study.

The findings are published online in Molecular Psychiatry, and may provide a target for future antidepressant medications with procognitive actions.

Cognitive impairments, such as diminished concentration or indecisiveness, are common in patients with MDD, but these symptoms have been difficult to model in animal studies.

Per Svenningsson, Therese Eriksson and colleagues determined that the rat depression model, Flinders Sensitive Line (FSL), exhibit comparable cognitive dysfunctions, such as impaired processing, and fail to avoid an unpleasant environment. After chronic treatment with the SSRI escitalopram - but not the tricyclic antidepressant nortriptyline - memory performance was restored.

The authors identified the molecular nodal points whereby the SSRI was effective, which could provide a target for future antidepressant medications with procognitive actions.

Explore further: Association between parental time pressure and mental health problems among children

More information: Emotional memory impairments in a genetic rat model of depression: involvement of 5-HT/MEK/Arc signaling in restoration
Molecular Psychiatry, online 18 januari 2011, DOI: MP.2010.131

add to favorites email to friend print save as pdf

Related Stories

Treating SSRI-resistant depression

Mar 25, 2008

When your antidepressant medication does not work, should you switch to a different medication from the same class or should you try an antidepressant medication that has a different mechanism of action" This is the question ...

A new generation of rapid-acting antidepressants?

Mar 01, 2010

Conventional antidepressant treatments generally require three to four weeks to become effective, thus the discovery of treatments with a more rapid onset is a major goal of biological psychiatry. The first drug found to ...

Recommended for you

Appraisal of stressful or threatening situations by the brain

6 hours ago

Researchers at the Research Center Translational Neurosciences of Johannes Gutenberg University Mainz (JGU) in Germany have advanced a generalized concept as the basis for future studies of mental resilience. Their new approach ...

Would you tell your manager you had a mental health problem?

Jan 26, 2015

Although nearly four in 10 workers wouldn't tell their manager if they had a mental health problem, half said that if they knew about a coworker's illness, they would desire to help, a new survey by the Centre for Addiction ...

Stress during pregnancy related to infant gut microbiota

Jan 26, 2015

Women who experience stress during pregnancy are likely to have babies with a poor mix of intestinal microbiota and with a higher incidence of intestinal problems and allergic reactions. This could be related to psychological ...

User comments : 0

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.