Getting more anti-cancer medicine into the blood

Jan 26, 2011

Scientists are reporting successful application of the technology used in home devices to clean jewelry, dentures, and other items to make anticancer drugs like tamoxifen and paclitaxel dissolve more easily in body fluids, so they can better fight the disease. The process, described in ACS' journal, Langmuir, can make other poorly soluble materials more soluble, and has potential for improving the performance of dyes, paints, rust-proofing agents and other products.

In the report, Yuri M. Lvov and colleagues point out that many drugs, including some of the most powerful anti-cancer medications, have low solubility in water, meaning they do not dissolve well. IV administration of large amounts can lead to clumping that blocks small , so doses sometimes must be kept below the most effective level. In addition, drug companies may discontinue work on very promising potential new drugs that have low solubility. The scientists note numerous efforts to improve the solubility of such medications, none of which have been ideal.

The scientists describe using sonification, high-pitched like those in home ultrasonic jewelry and denture cleaners, to break anti-cancer drugs into particles so small that thousands would fit across the width of a human hair. Each particle of that power then gets several coatings with natural polysaccharides that keep them from sticking together. The technique, termed nanoencapsulation, worked with several widely used anti-cancer drugs, raising the possibility that it could be used to administer more-effective doses of the medications. The report also described successful use to increase the solubility of ingredients in rust proofing agents, paints, and dyes.

Explore further: Scientists uncover clues to ATP mystery and how cells work

More information: "Converting Poorly Soluble Materials into Stable Aqueous Nanocolloids" Langmuir.

add to favorites email to friend print save as pdf

Related Stories

Tiny delivery system with a big impact on cancer cells

Dec 15, 2008

Researchers in Pennsylvania are reporting for the first time that nanoparticles 1/5,000 the diameter of a human hair encapsulating an experimental anticancer agent, kill human melanoma and drug-resistant breast ...

Soft drink could enhance effects of an anti-cancer drug

Oct 13, 2010

Experiments with an artificial stomach suggest that a popular lemon-lime soft drink could play an unexpected role in improving the effectiveness of an oral anticancer drug. The experiments produced evidence that patients ...

Recommended for you

Scientists uncover clues to ATP mystery and how cells work

58 minutes ago

(Phys.org) —Strong, thin fibers called microfilaments, or actin filaments, are present in the cytoplasm of almost every cell in the body. By growing and shrinking, actin filaments play a major role in cellular ...

A refined approach to proteins at low resolution

Sep 19, 2014

Membrane proteins and large protein complexes are notoriously difficult to study with X-ray crystallography, not least because they are often very difficult, if not impossible, to crystallize, but also because ...

User comments : 0