Scientists identify pomegranate juice components that could stop cancer from spreading

Dec 12, 2010
Manuela Martins-Green is a professor of cell biology at UC Riverside. Credit: UCR Strategic Communications.

Researchers at the University of California, Riverside have identified components in pomegranate juice that both inhibit the movement of cancer cells and weaken their attraction to a chemical signal that promotes the metastasis of prostate cancer to the bone. The research could lead to new therapies for preventing cancer metastasis.

Performed in the lab of Manuela Martins-Green, a professor of cell biology, the research was presented today (Dec. 12, 2010) at the 50th annual meeting of the American Society for Cell Biology taking place in Philadelphia.

is the second-leading cause of cancer-related deaths in men in the United States. To date, there is no cure for it. If prostate cancer recurs after treatments of surgery and/or radiation, usually the next treatment is the suppression of the male hormone testosterone, which inhibits the growth of the cancer cells because they need this hormone to grow. But over time, the cancer develops ways to resist hormone suppression therapies, becomes very aggressive, and metastasizes to the bone marrow, lungs, and lymph nodes, usually resulting in the patient's death.

The Martins-Green lab applied on laboratory-cultured that were resistant to testosterone (the more resistant a cancer cell is to , the more prone it is to metastasizing).

The researchers – Martins-Green, graduate student Lei Wang and undergraduate students Andre Alcon and Jeffrey Ho – found that the pomegranate juice-treated tumor cells that had not died with the treatment showed increased cell adhesion (meaning fewer cells breaking away) and decreased cell migration.

Next, the researchers identified the following active groups of ingredients in pomegranate juice that had a molecular impact on cell adhesion and migration in metastatic prostate cancer cells: phenylpropanoids, hydrobenzoic acids, flavones and conjugated fatty acids.

"Having identified them, we can now modify cancer-inhibiting components in pomegranate juice to improve their functions and make them more effective in preventing prostate , leading to more effective drug therapies," Martins-Green said. "Because the genes and proteins involved in the movement of prostate cancer cells are essentially the same as those involved in the movement of other types of cancer cells, the same modified components of the juice could have a much broader impact in cancer treatment."

Martins-Green explained that an important protein produced in the bone marrow causes the cancer cells to move to the bone where they can then form new tumors.

"We show that pomegranate juice markedly inhibits the function of this protein, and thus this juice has the potential of preventing metastasis of the prostate cancer cells to the bone," Martins-Green said.

Next, her lab plans to do additional tests in an in vivo model for prostate cancer metastasis to determine whether the same cancer-inhibiting components that work in cultured cells can prevent metastasis without side effects.

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User comments : 4

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Ratfish
5 / 5 (2) Dec 12, 2010
I wonder if these compounds can reach the tumor cells in the proper forms after digestion.
HaveYouConsidered
not rated yet Dec 12, 2010
Who's funding this work?
epsi00
not rated yet Dec 12, 2010
not pomegranate producers.
geniusW
5 / 5 (4) Dec 13, 2010
I think people are totally missing the point here. Pomegranate juice does have some very active compounds and I'm not surprised at all if they inhibit cancer metastasis. However, one should keep in mind nearly all plants have some kind of defense mechanism, and the fact that science has only begun to investigate the thousands of compounds present in EACH of the millions of plants against trillions of possible interactions and dosages...presents an enormous challenge for research. I bet there are thousands or even millions of compounds which do similar things...we just haven't throughly investigated them yet.