Wide genetic testing for Lynch Syndrome cost effective

November 19, 2010

Widespread genetic testing for Lynch Syndrome appears to be a cost-effective strategy for identifying those at risk for colorectal and endometrial cancer, according to a report in Cancer Prevention Research, a journal of the American Association for Cancer Research.

was always assumed to be cost effective for those at high risk based on their family history, but this shows it would be cost effective in a wider population, similar to the cost effectiveness of mammography,” said Stephen Gruber, M.D., Ph.D., M.P.H., director for cancer prevention and control at the University of Michigan Comprehensive Cancer Center, and a lead researcher on the study.

Gruber and colleagues used a mathematical model developed by Archimedes Inc., which showed when risk, based on family history, was assessed starting at ages 25, 30 or 35, followed by genetic testing for those who had risk exceeding 5 percent, colorectal cancers could be reduced by 12.4 percent and endometrial cancers by 8.8 percent. The average cost effectiveness ratio, a measure of expenditure per life year gained by the new strategy would be $26,000, a value favorably below the often-quoted benchmark of $50,000.

The American Association for hosted a teleconference on these findings on Thursday, Nov. 18, 2010.

“This will affect a wide population by changing our thinking about risk for colon cancer. Young individuals will be able to have an assessment of their personal and family history using a computerized model that can help guide their colon cancer risk management for decades, and make it possible to prevent significant numbers of colon and associated cancers, especially in young people, for a very reasonable cost. It is a huge step forward in terms of bringing the benefits of cancer genetics to the broader population using tests that have, in the past, been considered too expensive,” said Garber.

Explore further: Model Predicts Colon Cancer Inheritable Genetic Defects

Related Stories

Model Predicts Colon Cancer Inheritable Genetic Defects

September 27, 2006

Researchers from the Johns Hopkins University and other institutions have developed a new prediction model for genetic defects known as Lynch syndrome, which predisposes families to develop colorectal cancer.

Colon cancer link to obesity uncovered

September 30, 2008

A new study reveals the first-ever genetic link between obesity and colon cancer risk, a finding that could lead to greater accuracy in testing for the disease, said a researcher at the University of Alabama at Birmingham ...

Recommended for you

How the finch changes its tune

August 3, 2015

Like top musicians, songbirds train from a young age to weed out errors and trim variability from their songs, ultimately becoming consistent and reliable performers. But as with human musicians, even the best are not machines. ...

Machine Translates Thoughts into Speech in Real Time

December 21, 2009

(PhysOrg.com) -- By implanting an electrode into the brain of a person with locked-in syndrome, scientists have demonstrated how to wirelessly transmit neural signals to a speech synthesizer. The "thought-to-speech" process ...


Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.