Scientists turn skin into blood (w/ Video)

Nov 07, 2010
McMaster Stem Cell and Cancer Research Institute stem cell isolation expert, Marilyne Levadoux-Martin, operating the FACS Aria II, a high-speed cell sorter used to isolate human stem cells

(PhysOrg.com) -- In an important breakthrough, scientists at McMaster University have discovered how to make human blood from adult human skin.

The discovery, published in the prestigious science journal Nature today, could mean that in the foreseeable future people needing for surgery, or treatment of other blood conditions like anemia will be able to have blood created from a patch of their own skin to provide transfusions. Clinical trials could begin as soon as 2012.

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Interview with Mick Bhatia, scientific director of McMaster’s Stem Cell and Cancer Research Institute.

Mick Bhatia, scientific director of McMaster's Stem Cell and Cancer Research Institute in the Michael G. DeGroote School of Medicine, and his team of researchers have also shown that the conversion is direct. Making blood from skin does not require the middle step of changing a skin stem cell into a pluripotent stem cell that could make many other types of human , then turning it into a blood stem cell.

"We have shown this works using human skin. We know how it works and believe we can even improve on the process," said Bhatia. "We'll now go on to work on developing other types of human cell types from skin, as we already have encouraging evidence."

The discovery was replicated several times over two years using human skin from both young and old people to prove it works for any age of person.

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Bhatia Nature animation

"The pioneering findings published today are the first to demonstrate that can be directly converted into , via a programming process that bypasses the pluripotent stage. Producing blood from a patient's own skin cells, has the potential of making HLA matching and paucity of donors a thing of the past," said Christine Williams, PhD, Director of Research in the Canadian Cancer Society Research Institute.

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otto1932
5 / 5 (1) Nov 07, 2010
Yah I think I saw this very thing on Buffy Vampire Slayer, when Willow did Warren in for killing her girlfriend. What a mess.
neiorah
not rated yet Nov 08, 2010
Sweet
Bob_Kob
not rated yet Nov 08, 2010
So... what cut off your arm to be able to convert it to enough blood or what? Where are we going to get all this skin from?
LivaN
5 / 5 (2) Nov 08, 2010
So... what cut off your arm to be able to convert it to enough blood or what? Where are we going to get all this skin from?


No, you only need a few cells, which then devide. Once your quantity is large enough you can convert them to blood cells. At least that's what the vid implies!
genastropsychicallst
1 / 5 (3) Nov 08, 2010
... ; bloodgroup: comma ...
DavidMcC
not rated yet Nov 09, 2010
Following on from genastrophysicalist's somewhat abbreviated comment, does this result imply that people have a skin group as well as a blood group. For that matter, could transplant rejection in general be related to some general "flesh group"?
Just asking, because it would have profound implications for transplants in general. However, if it was true, why wouldn't this have been noticed long ago?