Putting the squeeze on fat cells

Nov 22, 2010

From fad diets to exercise programs, Americans continue to fight the battle of the bulge. Now they'll have help from recent Tel Aviv University research that has developed a new method to look at how fat cells -- which produce the fat in our bodies -- respond to mechanical loads.

This might be the key to understanding how to control the amount of fat produced by , the holy grail of weight loss researchers, says Prof. Amit Gefen of Tel Aviv University's Department of Biomedical Engineering. His research is driven by the theory that fat cells, like bone or , are influenced by mechanical loads, defined as the amount of force or deformation placed on a particular area occupied by cells. By recreating the structure of fat cells using a newly-developed computer method, Prof. Gefen and his team of researchers can determine how much mechanical load can be tolerated by fat cells, and at what point the cells will begin to disintegrate.

The research, recently reported in the Journal of Biomechanics, has direct applications in weight loss programs, the treatment of bedsores and the management of chronic diabetes.

Bones in space, fat on the ground

According to Prof. Gefen, applying mechanical loads on tissues can affect many different cells within our bodies. For example, affects the of astronauts. When astronauts return home after a prolonged space flight, he explains, they are often confined to a wheelchair for a small period of time. The structures of their bones and muscles, which are determined by the cells that produce these structures, are weakened due to a lack of mechanical loads. This occurs because cells are deprived of "normal" mechanical stimulation, like walking.

Prof. Gefen believes that, much like bone or muscle cells, fat cells are also affected by mechanical loads. His new takes slices of laser confocal microscopy images of cells and reconstructs a whole, virtual version of an individual cell, allowing researchers to evaluate how that cell will respond to different mechanical stimuli. "We use these computer models to see how cells function under mechanical loading, much like simulations in structural engineering are used to test the strength of bridges or machines," he explains.

After assembling their "virtual" fat cells, Prof. Gefen and his group found that fat cells or lipids have a point where mechanical loads can disintegrate them, as well as a point at which they are able to resist disintegration. Prof. Gefen is now trying to determine the specific load magnitudes and frequencies for fat cells, perhaps using ultrasound at a supersonic frequency to vibrate the tissue.

Not all infomercials are light-weight

Those fat-busting "ab vibrators" that you can see on infomercials are on the right track, says Prof. Gefen, but the magnitude of mechanical loads and the frequency of their application need to be scientifically determined. Such information could be crucial to the future of our health, he says, noting that diabetes and obesity rates are rising. "Any treatment that would be effective in fighting obesity would also apply immediately to diabetes," he explains.

The next step for Prof. Gefen and his fellow researchers is to pin down the mathematical equations that allow for the dissolving of lipid droplets, then predict what a fat cell will do under certain levels of force. This will lead to better information on how to use mechanical loads to control the production of fat by fat cells -- whether this means applying a certain frequency of ultrasonic vibration, or simply spending more time in the gym.

Explore further: Synthetic biology on ordinary paper, results off the page

add to favorites email to friend print save as pdf

Related Stories

A lab rat -- created in the lab

Apr 13, 2010

It's illegal for health products with medical formulations to be accepted by the U.S. Food and Drug Administration without tests on animals -- a situation that has serious ethical and moral implications. New ...

Human virus makes fat stem cells fatter

Oct 25, 2006

U.S. research showing how a human virus targets fat stem cells to produce more, fatter, fat cells is providing insights into the study of obesity.

Fat-regenerating 'stem cells' found in mice

Oct 10, 2008

Researchers have identified stem cells with the capacity to build fat, according to a report in the October 17th issue of the journal Cell, a Cell Press publication. Although they have yet to show that the cells can renew ...

Recommended for you

Team advances genome editing technique

Oct 21, 2014

Customized genome editing – the ability to edit desired DNA sequences to add, delete, activate or suppress specific genes – has major potential for application in medicine, biotechnology, food and agriculture.

User comments : 0