'At-TRIB(1)-uting' a gene a new function in the liver

Nov 15, 2010

Specific, relatively uncommon variations at a region of human chromosome 8 have recently been linked to fat (lipid) levels in the blood that decrease an individual's risk of atherosclerosis (a disease of the major arterial blood vessels that is a main cause of heart attack and stroke). The only currently described gene in this region of chromosome 8 is TRIB1, but it has not been previously linked in any way to regulation of lipid levels.

Now, a team of researchers, led by Jan Breslow, at The Rockefeller University, New York, and Daniel Rader, at the University of Pennsylvania School of Medicine, Philadelphia, has identified in mice a role for this gene in regulating lipid production by the liver.

Specifically, overexpression of Trib1 in the decreased levels of lipids such as cholesterol in the blood, while lack of Trib1 increased levels of the same lipids. These data suggest that TRIB1 is the gene responsible for the associations between chromosome 8 and lipid levels in the blood.

Explore further: Protein may improve liver regeneration

More information: Trib1 is a lipid- and myocardial infarction–associated gene that regulates hepatic lipogenesis and VLDL production in mice. View this article at: www.jci.org/articles/view/4421… 9213f656566ab4e5d75a

Related Stories

Link found between immune system and high plasma lipid levels

Apr 12, 2007

Researchers at the University of Chicago have found an unsuspected link between the immune system and high plasma lipid levels (cholesterol and triglycerides in the blood) in mice. The finding could lead to new ways to reduce ...

Mapping the genetic locus for triglycerides

Apr 25, 2008

Researchers have mapped out a region on human chromosome 1 that contributes to genetically elevated blood triglyceride levels, a major risk factor for heart disease.

Recommended for you

Computer model predicts how our livers will store fat

2 hours ago

As part of an effort to understand how an experimental drug for atherosclerosis causes the build-up of fat in the liver, scientists have developed a computer model that can predict how the rate at which liver stores fat in ...

Researchers identify "beige" fat-burning cells in humans

10 hours ago

For the first time, a research team, led by a UC San Francisco biologist, has isolated energy-burning "beige" fat from adult humans, which is known to be able to convert unhealthy white fat into healthy brown ...

User comments : 0

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.