Aggressive use of statins further cuts cardio risk: study

Nov 08, 2010

Higher doses of statins cut the risk of heart attacks and stroke by one-seventh compared with regular statin treatment, according to a review published online on Tuesday by The Lancet.

The study looked at five trials in which around 40,000 patients, advised to lower their levels of blood cholesterol, received either regular statin treatment or intensive treatment.

At the one-year point, intensive statins produced a "highly significant" additional reduction of 15 percent in cases of heart attack, coronary bypass and stroke compared with regular doses.

The analysis found no increase in cancer or mortality from non-cardiovascular disease.

The research was carried out by the Cholesterol Treatment Trialists' Collaboration, led by Colin Baigent, an Oxford University professor.

Statins, the biggest-selling in the world, work by reducing blood levels of artery-clogging "bad" cholesterol.

In a second study, also carried by The , British scientists found that, among high-risk patients, higher doses of statins reduced the risk of , blockage or stroke by six percent compared to lower doses.

There was no difference in cardiovascular fatalities.

The trial was conducted among 12,000 men and women who had previously had a . They received either 80 milligrams or 20 mg of simvastatin daily.

Explore further: Unsteady on your feet? Little touches could make all the difference

add to favorites email to friend print save as pdf

Related Stories

Statins shown to lower blood pressure

Apr 14, 2008

A large, randomized drug trial has shown for the first time that statin drugs result in a modest, but significant, reduction in blood pressure. These effects may contribute to the reduced risk of stroke and cardiovascular ...

Cholesterol-lowering drugs and the risk of hemorrhagic stroke

Dec 12, 2007

People taking cholesterol-lowering drugs such as atorvastatin after a stroke may be at an increased risk of hemorrhagic stroke, or bleeding in the brain, a risk not found in patients taking statins who have never had a stroke. ...

Recommended for you

Neutralising antibodies for safer organ transplants

11 hours ago

Serious complications can arise following kidney transplants. If dialysis is required within the first seven days, then the transplanted organ is said to have a Delayed Graft Function (DGF), and essentially ...

User comments : 1

Adjust slider to filter visible comments by rank

Display comments: newest first

deatopmg
1 / 5 (1) Nov 08, 2010
What were the side effects caused by the additional dose of these marginally effective drugs for reducing overall mortality?

"There was no difference in cardiovascular fatalities."