Vitamin D deficiency linked to lung transplant rejection

Oct 18, 2010

Vitamin D deficiency is associated with a significant increase in lung transplant rejection, according to research conducted at Loyola University Health System (LUHS). These data were presented Monday at The American Society for Bone and Mineral Research 2010 annual meeting in Toronto, Ontario.

"Vitamin D deficiency is prevalent among lung transplant recipients," said Pauline Camacho, MD, study investigator and director of the Loyola University Osteoporosis and Metabolic Bone Disease Center. "This study shed greater light on the serious impact that this deficiency has on lung transplant patients."

Patients who undergo lung transplants are at risk for rejecting the organ, and 77 percent of these patients are vitamin D deficient. Researchers believe that vitamin D helps the immune system tolerate the organ. Thus optimal levels of this supplement are critical for positive outcomes.

This study evaluated 122 patients who underwent a lung transplant at Loyola between January 2005 and June 2008. Sixty-four patients were male and 58 were female with an average age of 49.2 years. Vitamin D levels were checked following the transplants. Of the 122 patients, 50 percent were vitamin D deficient, 18 percent were not deficient and 32 percent were unknown. Vitamin D deficiency was associated with a significant increase in rejection for 51.7 percent of patients during the first year following transplant. also showed a trend toward increased airway inflammation in 16.7 percent of patients.

The health benefits of vitamin D are widespread and range from warding off cancer, osteoporosis, heart disease, diabetes and depression. Researchers speculate that vitamin D also may improve the health of patients. Further studies will evaluate the effect of vitamin D therapy on short- and long-term lung rates, lung function and long-term survival.

Explore further: Sporting events should ditch nutritional supps and sports drinks sponsorship

add to favorites email to friend print save as pdf

Related Stories

'Let the sunshine in' to protect your heart this winter

Nov 17, 2008

The temperature might not be the only thing plummeting this winter. Many people also will experience a decrease in their vitamin D levels, which can play a role in heart disease, according to a new review article in Circulation.

Weekly and biweekly vitamin D2 prevents vitamin D deficiency

Oct 26, 2009

Boston University School of Medicine researchers (BUSM) have found that 50,000 International Units (IU) of vitamin D2, given weekly for eight weeks, effectively treats vitamin D deficiency. Vitamin D2 is a mainstay for the ...

Recommended for you

We drink more alcohol on gym days

5 hours ago

A new Northwestern Medicine study finds that on days when people exercise more—typically Thursdays to Sundays—they drink more alcohol, too.

Obesity and stress pack a double hit for health

10 hours ago

If you're overweight, you may be at greater risk for stress-related diseases like type 2 diabetes, cardiovascular disease and cancer, according to a new study by Brandeis University.

User comments : 0