Soy intake associated with lower recurrence of breast cancer in hormone-sensitive cancers

Oct 18, 2010

Post-menopausal breast cancer patients with hormone-sensitive cancers who consumed high amounts of soy isoflavones had a lower risk of recurrence, found a research study published in CMAJ (Canadian Medical Association Journal).

Soy isoflavones are similar to estrogen in chemical structure and may stimulate or inhibit estrogen-like action in tissues. Consumption of isoflavones, found in soybeans and soy products, has increased in recent years and there are concerns about the effect of soy consumption on women with estrogen and progesterone receptor positive breast cancer as tumour growth is dependent on .

The study, by researchers at the Cancer Hospital of Harbin Medical University, Harbin, China, involved 524 women who had surgery for breast cancer and were followed afterwards for between five to six years. Since little is known about the effects of soy isoflavones on breast cancer patients receiving adjuvant endocrine therapy, the researchers sought to understand its impact in these patients.

"Compared with postmenopausal patients in the lowest quartile of soy isoflavone intake (less than 15.2 mg/day), those in the highest quartile (more than 42.3 mg/day) had a significantly lower risk of recurrence," writes Dr. Qingyan Zhang with coauthors.

"The recurrence rate of estrogen- and progesterone- positive was 12.9% lower among patients in the highest quartile of soy isoflavone intake than among those in the lowest quartile and was 18.7% lower for patients receiving anastrozole therapy in the highest quartile," they state.

However, there was no effect on overall survival in postmenopausal women and no association between soy intake and survival in premenopausal women.

The authors conclude that while this finding is potentially important regarding soy intake, large multicentre clinical trials are needed to provide more data.

Explore further: Urine HPV test could offer non-invasive alternative to conventional smear, improve screening uptake

add to favorites email to friend print save as pdf

Related Stories

Soy estrogens and breast cancer: Researcher offers overview

May 16, 2007

Are soy products healthy additions to a person's diet, safe alternatives to hormone-replacement therapy or cancer-causing agents" The answer, according to University of Illinois food science and human nutrition professor ...

Do soy isoflavones boost bone health?

Jul 30, 2010

Scientists already know much about the more than 200 bones that make up your body. But mysteries remain regarding the exact role that many natural compounds in foods might play in strengthening our skeletons. Those compounds ...

Soy found protective against localized prostate cancer

Mar 15, 2007

The largest study examining the relationship between the traditional soy-rich Japanese diet and development of prostate cancer in Japanese men has come to a seemingly contradictory conclusion: intake of isoflavone chemicals, ...

Recommended for you

User comments : 0