Scientists sequence genomes of lyme disease bacteria

Oct 18, 2010

Scientists supported by the National Institutes of Health (NIH) have determined the complete genetic blueprints for 13 different strains of Borrelia burgdorferi, the bacteria that cause Lyme disease.

The achievement should lead to a better understanding of how genetic variations among strains may result in different courses of illness in people with , the most common tickborne disease in North America. The wealth of new genetic data will also help scientists develop improved ways to diagnose, treat and prevent Lyme disease.

The first genome of a strain of B. burgdorferi was sequenced more than 10 years ago. The 13 newly sequenced strains include ones isolated from humans and ticks and represent a range of geographic origins. Together, the genomes provide a more complete picture of scope of natural variations in the microbe and the disease it causes.

The sequencing and analysis was led by Claire M. Fraser-Liggett, Ph.D., of the University of Maryland School of Medicine, and was performed at a Microbial Sequencing Center funded by the NIH's National Institute of Allergy and Infectious Diseases (NIAID). The research project was initiated by Steven E. Schutzer, M.D., of the University of Medicine and Dentistry of New Jersey-New Jersey Medical School, an NIAID grantee.

Additional support was provided by the National Institute of General Medical Sciences and the National Center for Research Resources, both components of NIH.

Explore further: New concepts based on advances in animal systematics

More information: SE Schutzer et al. Whole genome sequences of thirteen isolates of Borrelia burgdorferi. J. Bacteriology DOI:10.1128/JB.01158-01 (2010).

Provided by National Institutes of Health

5 /5 (1 vote)
add to favorites email to friend print save as pdf

Related Stories

Genetic blueprint of bacteria causing Lyme disease unraveled

Oct 14, 2010

Benjamin Luft, M.D., Professor of Medicine, Stony Brook University Medical Center, and a team of medical researchers have determined the genetic blueprint of 13 strains of the bacteria that cause Lyme disease. The finding ...

Researchers to study lyme-like illness in Texas

Aug 15, 2008

Tao Lin, D.V.M., and Steven J. Norris, Ph.D., both with the Department of Pathology and Laboratory Medicine at The University of Texas Medical School at Houston, have been named grant recipients of the Norman Hackerman Advanced ...

Birds Play an Important Role in the Spread of Lyme Disease

Dec 23, 2009

(PhysOrg.com) -- The range of Lyme disease is spreading in North America and it appears that birds play a significant role by transporting the Lyme disease bacterium over long distances, a new study by the Yale School of ...

Recommended for you

Iberian pig genome remains unchanged after five centuries

12 hours ago

A team of Spanish researchers have obtained the first partial genome sequence of an ancient pig. Extracted from a sixteenth century pig found at the site of the Montsoriu Castle in Girona, the data obtained indicates that ...

New concepts based on advances in animal systematics

14 hours ago

The way in which most multicellular organisms have been classified has been the same for more than a century. Only recently have scientists developed the tools and knowledge to question the way we classify ...

New dawn for pasta wheat in Australia

18 hours ago

The University of Adelaide's durum breeding program today at the Hart Field Day will release a new durum wheat variety called DBA-Aurora which promises a step-change in potential durum production in southern Australia.

User comments : 0