New polio vaccine raises hope for eradication: study

Oct 26, 2010

A new polio vaccine offers superior immunisation and is raising hopes of a total eradication of the disease, according to a study published on Tuesday by British medical journal The Lancet.

There are three types of the virus, and while type 2 has been almost entirely eradicated since mass vaccinations began in 1988, types 1 and 3 remain a global health threat.

The new bivalent vaccine targets types 1 and 3, and was shown to be significantly more effective than the common trivalent vaccine in a 2008 trial in India.

In the trial, conducted by experts from the World Health Organisation and India, 830 new-born babies at three medical centres were give either existing vaccines or the new bivalent vaccine.

The new vaccine presented immunity against type 1 polio in 90 percent of babies, compared with 63 percent from the trivalent vaccine. The new vaccine presented 74 percent immunity for type 3, against 52 percent with the trivalent vaccine. A monovalent vaccine for type 3 led to 84 percent immunity.

Polio is a threat in four countries, namely India, Afghanistan, Pakistan and Nigeria, compared to 125 countries in 1988. There were 1,606 cases of polio last year, down from about 350,000 in 1988.

The new is already being widely used in India, and the number of polio cases was down to 32 so far this year, from 260 last year, the journal said, quoting researchers Nigel Crawford and Jim Buttery from the Murdoch Children's Research Institute in Melbourne, Australia.

The researchers warned that progress in polio immunisation was being undermined by a lack of funds, and called for a "final, concerted effort" to stamp it out.

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