Type 2 diabetes and insulin use are associated with colorectal cancer in men

Oct 18, 2010

There is an association between type 2 diabetes mellitus and colorectal cancer (CRC) among men, but not women, according to a new study in Gastroenterology, the official journal of the American Gastroenterological Association (AGA) Institute.

In 2000, the prevalence of was approximately 171 million worldwide, and 366 million people are projected to have the disease by 2030. Obesity, western-style diet and lack of are established risk factors for CRC. and hyperinsulinemia, which are especially pronounced during the early stages of type 2 diabetes, have been proposed as mediators for the association between CRC and type 2 diabetes. Although it is known that type 2 diabetes is associated with an increased risk of CRC, it is not clear if this association varies by gender or other factors.

"While our study supports an association of type 2 diabetes with colorectal cancer incidence among , our results also suggest that insulin use is associated with a slight, but not a substantially increased, risk of colorectal cancer among men with type 2 diabetes," said Peter T. Campbell, PhD, of the American Cancer Society and lead author of this study. "Prevention strategies should emphasize adherence to guidelines intended for the general population such as smoking cessation, , exercise and regular early detection exams."

This video is not supported by your browser at this time.
Watch Dr. Campbell discuss his study

In the final study of 73,312 men and 81,663 women, 1,567 men (227 with type 2 diabetes) and 1,242 women (108 with type 2 diabetes) were diagnosed with colon or rectal cancer by 2007. Among men, type 2 diabetes was associated with increased risk of incident CRC compared to not having type 2 diabetes. CRC risk was higher for those participants with type 2 diabetes regardless of whether or not they used insulin.

Among women, type 2 diabetes and use were not associated with CRC risk. These findings support recent observations that the association may be more prominent in men than in women, and raise the possibility of a stronger association among individuals with a family history of CRC. This finding could have clinical relevance if confirmed by other large studies. The authors speculate that the lack of an association between type 2 diabetes and CRC risk among women might relate to improved glucose control among women with type 2 diabetes in recent years.

Participants were selected from the Cancer Prevention Study II Nutrition Cohort, a prospective study of incidence. In 1992 or 1993, 184,194 adult participants completed a detailed, self-administered questionnaire. Follow-up questionnaires were sent in 1997 and every two years thereafter.

Explore further: Use of frozen material for fecal transplant successfully treats C. difficile infection

add to favorites email to friend print save as pdf

Related Stories

Birth records hold pancreatic cancer clue

Aug 16, 2007

Pregnancies in Jerusalem in the 1960s and 1970s may hold vital clues about how pancreatic cancer and diabetes are linked. According to research published in the online open access journal BMC Medicine, women with a history ...

No heart benefit from Omega-3 in women with type 1 diabetes

Jun 27, 2010

Consuming higher amounts of omega-3 fatty acids does not appear to lower heart disease risk for women with type 1 diabetes, according to a University of Pittsburgh Graduate School of Public Health study being presented at ...

Diabetes may double cancer risk in women

Jun 10, 2010

Type 2 adult-onset diabetes causes insulin-like hormones to circulate through the body. A new study finds this has a surprisingly positive effect on reducing the rate of prostate cancer in men, but is bad news for women: ...

Can too much HDL be harmful to women with type 1 diabetes?

Jun 27, 2010

Elevated blood levels of high-density lipoprotein (HDL) or "good" cholesterol, typically thought to protect against heart disease, may do the opposite in women with type 1 diabetes, according to a University of Pittsburgh ...

Recommended for you

Saudi Arabia reports pilgrim infected with MERS

2 hours ago

In the past 24 hours, Saudi Arabia has reported four new deaths from a Middle East virus related to SARS and 36 more cases of infection, including a Turkish pilgrim in Mecca.

User comments : 0

More news stories

Autism Genome Project delivers genetic discovery

A new study from investigators with the Autism Genome Project, the world's largest research project on identifying genes associated with risk for autism, has found that the comprehensive use of copy number variant (CNV) genetic ...

Study suggests targeting B cells may help with MS

A new study suggests that targeting B cells, which are a type of white blood cell in the immune system, may be associated with reduced disease activity for people with multiple sclerosis (MS). The study is released today ...

Study links California drought to global warming

While researchers have sometimes connected weather extremes to man-made global warming, usually it is not done in real time. Now a study is asserting a link between climate change and both the intensifying California drought ...