Low birth weight may lead to poor growth rate in children with kidney disease

Oct 28, 2010

The lower the birth weight, the greater the chance of poor growth rate in children with chronic kidney disease (CKD), according to a new study appearing in an upcoming issue of the Clinical Journal of the American Society of Nephrology (CJASN).

In the general population, is not an important cause of poor growth and short stature. To determine whether low birth weight is a risk factor for poor growth in children with CKD, Larry Greenbaum, MD, PhD (Emory University and Children's Healthcare of Atlanta, Atlanta, GA) and his colleagues analyzed results from the in Children Prospective Cohort (CKiD) study. Study participants included 426 out of the 586 children enrolled in the CKID study, all of whom had mild to moderate CKD and were in 48 pediatric nephrology centers across North America.

"This is the first study showing an association between low birth weight and poor growth in children with CKD," explains Dr. Greenbaum. "The study also demonstrates that children with CKD are more likely to be born with low birth weight than the general population. This occurs in children who are born with kidney disease and those who acquire kidney disease during childhood. It is possible that low birth weight is a risk factor for the development of kidney disease during childhood."

Limitations: This study shows an association between low birth weight and poor growth in children with CKD but does not prove that the low birth weight causes poor growth. The study also does not indicate why low birth weight may lead to poor growth in children with CKD.

Take-away message: Additional research is needed to determine if being born small increases the risk of developing kidney disease during childhood. Previous research has shown that adults who were smaller at birth were more likely to have kidney disease.

Explore further: Ebola expert calls for European anti-virus 'corps'

More information: The article, entitled "The Association between Abnormal Birth History and Growth in Children with CKD," will appear online on October 28, 2010, doi:10.2215/CJN.08481109

add to favorites email to friend print save as pdf

Related Stories

Low thyroid function common in chronic kidney disease

Jun 11, 2008

Many patients with chronic kidney disease (CKD) have mild reductions in thyroid function, or subclinical hypothyroidism—a condition that becomes more common as kidney function declines, according to a study in the September ...

Recommended for you

Ebola expert calls for European anti-virus 'corps'

Dec 26, 2014

Europe will be "vulnerable" if it does not regard viruses as a "national security issue" like the United States, the microbiologist who discovered Ebola said in an interview published Friday.

In Liberia, Ebola steals Christmas

Dec 26, 2014

The Ebola epidemic has cast a dark shadow over Christmas this year in Liberia, where small businesses are especially feeling the pinch.

Firm recalls caramel apples amid listeria fears

Dec 25, 2014

A Missouri firm is recalling its Happy Apple brand caramel apples because of the potential that they could be contaminated with listeria. The recall comes after at least three deaths and at least 29 illnesses in 10 states ...

User comments : 0

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.