Scientists unwrap DNA packaging to gain insight into cells

September 2, 2010

Scientists have built a clearer picture of how lengthy strands of DNA are concertinaed when our cells grow and divide, in a discovery could help explain how cell renewal can go wrong.

Scientists have identified thousands of proteins that play a key role in compacting DNA - a crucial process by which DNA is shortened up to 10,000 times to fit inside as they split into two.

Researchers hope the findings could shed light on what happens when this packaging process fails and cells divide abnormally - which can lead to cancer or cause developing to miscarry.

Scientists developed a new technology for their research by combining existing techniques in biology, genetics and maths and the large-scale study of proteins. They were able to define some 4,000 proteins involved in the division of cells. The proteins protect the fragile and help it fold into the correct shape before it splits into two new cells. The new methods can identify many of those proteins that are most important to the process.

University of Edinburgh scientists, who carried out the study, hope the discovery will help them better understand how these proteins influence the process of cell division.

The research was carried out in collaboration with the University of Oxford and the Japanese National Institute of Genetics in Mishima, Japan. It was supported by the Wellcome Trust and published in the journal Cell.

Professor William Earnshaw of the University of Edinburgh's School of Biological Sciences, who directed the study with Professor Juri Rappsilber, said: "Until now, our understanding of the very complex way in which moves during cell division was patchy - this latest development allows us, for the first time, to fully identify all the proteins that take part in the process, and how they interact with one another. Future work is needed to reveal more of the intricacies of this process and how to prevent it from going wrong."

Explore further: Study: Sugar helps control cell division

Related Stories

Study: Sugar helps control cell division

September 21, 2005

Johns Hopkins scientists in Baltimore say they've discovered a deceptively simple sugar is really a critical regulator of cells' natural life cycle.

Researchers shed light on how tumor cells form

June 21, 2006

MIT cancer researchers have discovered a process that may explain how some tumor cells form, a discovery that could one day lead to new therapies that prevent defective cells from growing and spreading.

A new cellular pathway linked to cancer is identified

July 24, 2008

In the life of a cell, the response to DNA damage determines whether the cell is fated to pause and repair itself, commit suicide, or grow uncontrollably, a route leading to cancer. In a new study, published in the July 25th ...

Recommended for you

Male seahorse and human pregnancies remarkably alike

September 1, 2015

Their pregnancies are carried by the males but, when it comes to breeding, seahorses have more in common with humans than previously thought, new research from the University of Sydney reveals.

Parasitized bees are self-medicating in the wild, study finds

September 1, 2015

Bumblebees infected with a common intestinal parasite are drawn to flowers whose nectar and pollen have a medicinal effect, a Dartmouth-led study shows. The findings suggest that plant chemistry could help combat the decline ...

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.