National Jewish Health receives patent for liposome-based vaccine

Sep 27, 2010

(PhysOrg.com) -- National Jewish Health has received a US patent for a new kind of vaccine, which uses a small lipid bubble to deliver an antigen and DNA adjuvant.

Chairman of Pediatrics Erwin Gelfand, MD, and former National Jewish Health Professor of Medicine Steve Dow, PhD, developed the new liposome-based adjuvant.

Live vaccines, containing weakened forms of an infectious organism, generally work fine by themselves. But vaccines containing dead organisms or pieces of the infectious organisms or their toxins generally need adjuvants to boost their effectiveness. Aluminum salts, known as alum, are the most common adjuvant used in the United States for routine preventive vaccines.

The recently patented invention by Drs. Gelfand and Dow describes a contained within a liposome, a tiny vesicle made of a double layer of lipids. Contained within the liposome is a DNA sequence that serves as an adjuvant. Depending on the sequence, either the DNA molecule itself or the protein for which it codes can be used to stimulate the immune system. This is fused to an immunogen, the protein fragment against which the immune mounts a specific attack. The protein fragment could be part of an infectious organism or possibly some other health hazard such as a cancer tumor. The liposome-based vaccine could be delivered either subcutaneously through injection or orally.

The patent, #7741300, (patft.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PALL&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.htm&r=1&f=G&l=50&s1=7741300.PN.&OS=PN/7741300&RS=PN/7741300) is currently licensed to a US biotechnology company for commercial development.

Explore further: Teva to lift bid for Mylan: report

Related Stories

New 'adjuvant' could hold future of vaccine development

Sep 14, 2009

Scientists at Oregon State University have developed a new "adjuvant" that could allow the creation of important new vaccines, possibly become a universal vaccine carrier and help medical experts tackle many diseases more ...

Tattooing improves response to DNA vaccine

Feb 07, 2008

A tattoo can be more than just a fashion statement – it has potential medical value, according to an article published in the online open access journal, Genetic Vaccines and Therapy.

Recommended for you

Teva to lift bid for Mylan: report

23 hours ago

Israeli pharmaceutical giant Teva plans to increase its bid for rival Mylan and could announce the move as soon as this week, according to a US media report Monday.

Vaccine for West Nile Virus enters human clinical trials

Jul 06, 2015

A clinical trial of a new investigational vaccine designed to protect against West Nile Virus infection will be sponsored by the National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes ...

FDA clears drug for leading form of cystic fibrosis

Jul 02, 2015

Federal health officials have approved a new combination drug for the most common form of cystic fibrosis, the debilitating inherited disease that causes internal mucus buildup, lung infections and early death. But it will ...

User comments : 0

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.