Post-surgery radiation improves breast cancer survival

August 31, 2010 by Dorsey Griffith

Radiation therapy following surgery for a rare type of breast cancer improves patient survival, according to a study by a team of surgical oncologists at UC Davis Cancer Center.

Adenoid cystic carcinoma, a tumor type that represents less than 1 percent of all breast carcinomas, generally is treated with surgery alone, either lumpectomy or . Steven Chen, assistant professor of surgical oncology, wanted to find out if adding radiation therapy to surgery would improve outcomes for patients.

Chen's research was sparked by a patient whom he cared for two years ago. "I had seen a patient with this type of cancer, and wasn't sure what to do with her after surgery," Chen said. "I wondered if she was supposed to get radiation therapy."

Chen took the case to a meeting of other cancer specialists. All agreed that there was no solid evidence available about the value of radiation therapy for this type of tumor. Physicians do not like to give patients any when it is not clear that it could be effective.

Published online this month in the Journal of Surgical Oncology, Chen's study identified 376 patients across the country diagnosed with adenoid cystic carcinoma of the breast in the Surveillance, Epidemiology, and End Results (SEER) registry maintained by the National Cancer Institute. All of the patients had undergone surgery between 1988 and 2005. Among them, 129 (34 percent) also had received radiation therapy.

"We found that the women who got did better," Chen said. "Even after accounting for age, tumor stage and type of surgery, radiation therapy still cut the death rate by 56 percent overall."

Among women who had radiation therapy after lumpectomy, survival rates after five years for those undergoing surgery and radiation were 94 percent; survival rates were 82 percent for those having surgery alone. By 10 years, that gap had widened: 86 percent of those undergoing radiation were still alive, whereas only 67 percent of those having surgery alone were still alive.

Because of the relatively small number of patients in the study, results were limited to women with early-stage disease. And because so few of the women in the study had a mastectomy, the sample was too small to determine a benefit from radiation therapy for those patients.

Chen hopes the research gives cancer specialists helpful information in choosing therapeutic approaches for patients with this type of breast cancer.

"We hope surgical oncologists will see this study and start referring patients to radiation oncology more often," he said. "There are good reasons why a woman might choose not to have , but they won't have an opportunity to have that discussion if they don't get a referral."

Explore further: Combining radiation and surgery significantly improves survival for head and neck cancer patients

Related Stories

Second lumpectomy for breast cancer reduces survival rates

October 2, 2008

A majority of women with breast cancer today are candidates for lumpectomy, allowing for conservation of most of their breast tissue. Results of a UC Davis study, however, show that a number of women whose cancer recurs in ...

Radiation after mastectomy underused, study finds

March 29, 2010

While radiation therapy is common after breast conserving surgery, it's much less frequent after mastectomy, even among women for whom it would have clear life-saving benefit. This is according to a new study from researchers ...

Recommended for you

How the finch changes its tune

August 3, 2015

Like top musicians, songbirds train from a young age to weed out errors and trim variability from their songs, ultimately becoming consistent and reliable performers. But as with human musicians, even the best are not machines. ...

Cow embryos reveal new type of chromosome chimera

May 27, 2016

I've often wondered what happens between the time an egg is fertilized and the time the ball of cells that it becomes nestles into the uterine lining. It's a period that we know very little about, a black box of developmental ...

Shaving time to test antidotes for nerve agents

February 29, 2016

Imagine you wanted to know how much energy it took to bike up a mountain, but couldn't finish the ride to the peak yourself. So, to get the total energy required, you and a team of friends strap energy meters to your bikes ...


Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.