Impaired activity of the protein MTOR a strain on the heart

July 19, 2010

A team of researchers, led by Gianluigi Condorelli, at the University of California San Diego, La Jolla, has generated data in mice that suggest that drugs that inhibit the protein MTOR, which are used to treat several forms of cancer, might have adverse effects on heart function in patients with ongoing heart dysfunction.

In the study, it was found that adult mice lacking MTOR in their heart muscle cells developed a fatal heart condition. Disease was associated with accumulation of the protein 4E-BP1, which is an inhibitor of protein generation that is normally held in check by a complex containing MTOR.

Further analysis indicated that in a model of high blood pressure the mice lacking MTOR in their heart muscle cells developed heart failure more quickly than did normal mice. Importantly, deletion of 4E-BP1 under these conditions improved heart function and survival.

Thus, decreased MTOR activity impairs the protective heart response to stress, by enhancing 4E-BP1 activity, providing a potential new therapeutic strategy for improving heart function in patients with and a warning to clinicians using MTOR inhibitors.

Explore further: Dietary copper may ease heart disease

More information:

Related Stories

Dietary copper may ease heart disease

March 5, 2007

Including more copper in your everyday diet could be good for your heart, according to scientists at the University of Louisville Medical Center and the USDA Human Nutrition Research Center. Their studies show that giving ...

The beat goes on with AKAP18

September 28, 2007

A protein, known as AKAP18, could help the heart to beat faster in response to adrenaline or noradrenaline, according to a study published online this week in EMBO reports.

Study: Fountain of youth for your heart?

November 2, 2007

An age-related decline in heart function is a risk factor for heart disease in the elderly. While many factors contribute to a progressive age-related decline in heart function, alterations in the types of fuels the heart ...

Treating heart failure with a gas

November 11, 2008

At low concentrations, the toxic gas hydrogen sulfide protects the hearts of mice from heart failure, scientists at Emory University School of Medicine have found.

I-1c gene therapy: Not such a good idea in heart failure?

January 12, 2010

Several lines of evidence, including the observation that the protein I-1 is downregulated in human failing hearts, have led to the suggestion that gene therapy to express a constitutively active form of the protein (I-1c) ...

Recommended for you

How the finch changes its tune

August 3, 2015

Like top musicians, songbirds train from a young age to weed out errors and trim variability from their songs, ultimately becoming consistent and reliable performers. But as with human musicians, even the best are not machines. ...

Machine Translates Thoughts into Speech in Real Time

December 21, 2009

( -- By implanting an electrode into the brain of a person with locked-in syndrome, scientists have demonstrated how to wirelessly transmit neural signals to a speech synthesizer. The "thought-to-speech" process ...


Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.