New 'microbead' radiotherapy more effective with molecular imaging

Jun 07, 2010

Research unveiled at SNM's 57th Annual Meeting may change the way that a novel form of radiotherapy is set up and tested prior to treatment. This technique, known as radiomicrosphere therapy, involves the injection of tiny highly radioactive beads that "nestle up" with cancerous tumors and destroy them with precision. However, technologists and physicians must work together to carefully plan each patient's treatment using molecular imaging to ensure that the beads do not wander off into other areas of the body.

"Radiomicrosphere therapy guided by molecular imaging is an emerging area of radiotherapy and has the potential to target treatments for patients," said Ron Young, C.N.M.T., principal researcher and clinical manager of nuclear medicine at the Cleveland Clinic, Cleveland, Ohio. "This technique allows us to provide the most effective and individualized therapy with minimal complications for the patient."

Radiomicrosphere therapy can lead to unwanted damage to healthy tissues. Young emphasizes that those providing care must perform an imaging scan of patients to predict where these particles are going to travel and potentially destroy normal tissue. A form of called SPECT/CT, which combines single photon emission computed tomography and X-ray computed tomography, may be the best tool for determining the likely path of these cancer-killing microbeads. With this form of , also called radioembolization, tiny beads are impregnated with a and injected into the liver with a inserted through the groin. Prior to therapy, technologists and nuclear medicine physicians simulate therapy by injecting patients with the imaging agent Tc99m-MAA, which emulates the migration pattern the spheres will take. Molecular and X-ray imaging with SPECT/CT technology provide the essential information interventional radiologists need to then block blood vessels surrounding the targeted organ with small metal coils, effectively isolating the microbeads during therapy.

In this study, 99 patients underwent conventional planar imaging with gamma camera technology followed by imaging with SPECT/CT prior to therapy. Only nine patients out of the 99 showed potential for "shunting" or bleeding of the radioactive particles into other areas of the body, leading to the destruction of healthy tissues. The use of SPECT/CT alone indicated that 23 patients, more than double that of more conventional imaging, showed potential for complications. Another patient's hepatic vein, the main blood vessel into the liver, was shown to be obstructed by the tumor, which informed the treating physician that therapy would need to be altered due to this obstruction. In this case, SPECT/CT was able to uncover a previously unknown complication that changed the course of treatment for the patient. According to the study, SPECT/CT makes radiomicrosphere therapy a more powerful and safer tool for cancer therapy.

Explore further: Second-line cetuximab active beyond progression in quadruple wild-type patients with mCRC

Related Stories

Clearing the way for detecting pulmonary embolism

Dec 01, 2009

When it comes to diagnosing pulmonary embolism—a sudden blockage in the lung artery that could be deadly if not treated—which technique is the most effective? Research published in the December issue of The Journal of ...

Open cancer surgery set to become a thing of the past

Sep 24, 2008

The surgeon's knife is playing an ever smaller role in the treatment of cancer, as it is replaced by increasingly efficient and safe radiation therapy techniques. Progress in radiation technology will also lead to better ...

Recommended for you

Spicy treatment the answer to aggressive cancer?

Jul 03, 2015

It has been treasured by food lovers for thousands of years for its rich golden colour, peppery flavour and mustardy aroma…and now turmeric may also have a role in fighting cancer.

Cancer survivors who smoke perceive less risk from tobacco

Jul 02, 2015

Cancer survivors who smoke report fewer negative opinions about smoking, have more barriers to quitting, and are around other smokers more often than survivors who had quit before or after their diagnosis, according to a ...

Melanoma mutation rewires cell metabolism

Jul 02, 2015

A mutation found in most melanomas rewires cancer cells' metabolism, making them dependent on a ketogenesis enzyme, researchers at Winship Cancer Institute of Emory University have discovered.

User comments : 0

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.