A useful tool to detect in vivo angiogenesis in IBD patients: Narrow-band imaging

May 20, 2010

A research team from Italy investigated whether narrow-band imaging (NBI) is a useful tool for the in vivo detection of angiogenesis in inflammatory bowel disease (IBD) patients. Their results showed NBI may be a novel modality for imaging of intestinal angiogenesis in IBD.

Angiogenesis plays a crucial role in neoplastic and non-neoplastic chronic inflammatory disorders, including inflammatory bowel diseases (IBD). Several reports have shown that blockade of angiogenesis in preclinical models of IBD is a promising new therapeutic approach. Visualize angiogenesis in vivo may represent the first step for such a therapeutic approach. Narrow-band imaging (NBI) is a new endoscopic technology that highlights mucosal surface structures and microcapillaries.

Performing the conventional and NBI in 14 patients with colonic inflammation (8 ulcerative colitis and 6 Crohn's disease), a research team from Italy analyzed the use of NBI for the in vivo detection of angiogenesis in IBD patients. Their study will be published on May 21, 2010 in the .

They found that NBI could be used to visualize areas of abnormal microvascular changes, not observed with white light colonoscopy. Blockade of angiogenesis could be beneficial in patients with and some drugs that have demonstrated efficacy for the treatment of IBD, such tumor necrosis factor-α inhibitors, have potent antiangiogenic activity. The findings suggest that NBI could be a novel tool for the in vivo assessment of mucosal angiogenesis. However, larger studies are needed to define the exact role of NBI in IBD patient follow-up.

Explore further: Il-22 gene delivers the goods and decreases intestinal inflammation

More information: Danese S, Fiorino G, Angelucci E, Vetrano S, Pagano N, Rando G, Spinelli A, Malesci A, Repici A. Narrow-band imaging endoscopy to assess mucosal angiogenesis in inflammatory bowel disease: A pilot study. World J Gastroenterol 2010; 16(19): 2396-2400. www.wjgnet.com/1007-9327/full/v16/i19/2396.htm

Related Stories

Promising probiotic treatment for inflammatory bowel disease

January 20, 2010

Bacteria that produce compounds to reduce inflammation and strengthen host defences could be used to treat inflammatory bowel disease (IBD). Such probiotic microbes could be the most successful treatment for IBD to date, ...

Recommended for you

How the finch changes its tune

August 3, 2015

Like top musicians, songbirds train from a young age to weed out errors and trim variability from their songs, ultimately becoming consistent and reliable performers. But as with human musicians, even the best are not machines. ...

Machine Translates Thoughts into Speech in Real Time

December 21, 2009

(PhysOrg.com) -- By implanting an electrode into the brain of a person with locked-in syndrome, scientists have demonstrated how to wirelessly transmit neural signals to a speech synthesizer. The "thought-to-speech" process ...

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.