New technology aids in prostate cancer treatment

May 12, 2010

Researchers at Queen's University have developed a new way of performing lab tests that could improve the way doctors manage prostate cancer treatment. It will allow them to identify with unprecedented accuracy losses of a gene called PTEN that is associated with an aggressive group of prostate cancers.

The improved Fluorescence In-Situ Hybridization (FISH) platform uses DNA probes to analyze the three-dimensional space cancer cells occupy in routine clinical microscopic analysis of tissue sections of tumors. It will provide a more accurate way of identifying PTEN loss in biopsies and tissue sections so doctors can better match the type and amount of treatment to the aggressiveness of a tumor.

"The idea is that this test could be used in new cases of to help decide which of the many options is best suited for more aggressive cancers " says Jeremy Squire, who worked with a team of researchers in the Department of Pathology and . "The patient treatment from the get-go will be more appropriately planned."

PTEN is found in the nucleus of and is considered one of the most important cancer-causing tumor-suppressor genes. If there is loss in the PTEN, it can inhibit the patient's ability to fight the cancer. It plays a critical role in a variety of cancers including prostate, breast, and lung cancers.

PARTEQ Innovations, the technology transfer office of Queen's University has licensed the technology to Cymogen Dx. The company expects to make the technology available to research and clinical markets in the near future.

Explore further: Second-line cetuximab active beyond progression in quadruple wild-type patients with mCRC

Related Stories

Preventing prostate cancer the complex way

Feb 03, 2009

(PhysOrg.com) -- Blocking a specific protein complex prevents the formation of tumors in mice genetically predisposed to develop prostate cancer, researchers at the Whitehead Institute for Biomedical Research ...

Gene helps protect tumor suppressor in breast cancer

Apr 06, 2009

Scientists at The University of Texas M. D. Anderson Cancer Center have discovered a gene that protects PTEN, a major tumor-suppressor that is reduced but rarely mutated in about half of all breast cancers.

Recommended for you

Spicy treatment the answer to aggressive cancer?

Jul 03, 2015

It has been treasured by food lovers for thousands of years for its rich golden colour, peppery flavour and mustardy aroma…and now turmeric may also have a role in fighting cancer.

Cancer survivors who smoke perceive less risk from tobacco

Jul 02, 2015

Cancer survivors who smoke report fewer negative opinions about smoking, have more barriers to quitting, and are around other smokers more often than survivors who had quit before or after their diagnosis, according to a ...

Melanoma mutation rewires cell metabolism

Jul 02, 2015

A mutation found in most melanomas rewires cancer cells' metabolism, making them dependent on a ketogenesis enzyme, researchers at Winship Cancer Institute of Emory University have discovered.

User comments : 0

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.