New Alzheimer vaccine to be tested in Europe

April 23, 2010

A new vaccine against Alzheimer's, developed by the Austrian biotechnology firm Affiris, will soon be tested in six European countries, the company announced Friday.

Some 420 patients will be recruited to take part in clinical trials in Austria, Croatia, Czech Republic, France, Germany and Slovakia, Affiris said in a statement.

The AD02 vaccine, developed with British drugmaker , was already tested for safety and tolerability over the past year.

The clinical trials will now test its efficacy, with results expected as early as 2012, the company said.

ADO2 is meant to prevent the building up of beta-amyloid plaques in the brain, which cause the degradation of and are believed to play a crucial role in causing Alzheimer's disease.

The vaccine works by causing the body to attack these plaques by producing more antibodies, Till Jelitto, a spokesman for Affiris, told AFP.

More specifically, these are meant to attack only the part of the beta-amyloid protein that causes the plaques, he added.

This would reduce the risk for patients, as the protein as a whole already exists in healthy individuals.

The current vaccine is therapeutic, meaning it is aimed at treating patients already affected by the disease. But if results are positive, the technology could also be used to manufacture a prophylactic, or preventative, vaccine, Jelitto said.

In 2001, tests for a first vaccine against Alzheimer's disease were conducted in the United States and Europe but had to be cut short after serious side effects emerged.

Another was tested in Sweden in 2005.

, also known as AD, is a neuro-degenerative disease that affects cognitive functions, further impacting patients' behaviour and social adaptation.

The disease, which still has no known cure, affects about six million people in Europe every year.

Affiris is also working on vaccines against Parkinson's and .

Explore further: Immune antibodies penetrate neurons to clear Alzheimer's-linked amyloid

Related Stories

Paving the way toward a vaccine against Alzheimer's disease

June 21, 2007

Scientists have provided new details about how proteins used to destroy bacteria and viruses may help treat Alzheimer’s disease. Gunnar K. Gouras, associate professor of neurology and neuroscience at Weill Medical College ...

Potatoes may hold key to Alzheimer's treatment

August 15, 2008

A virus that commonly infects potatoes bears a striking resemblance to one of the key proteins implicated in Alzheimer's disease (AD), and researchers have used that to develop antibodies that may slow or prevent the onset ...

Recommended for you

How the finch changes its tune

August 3, 2015

Like top musicians, songbirds train from a young age to weed out errors and trim variability from their songs, ultimately becoming consistent and reliable performers. But as with human musicians, even the best are not machines. ...

Machine Translates Thoughts into Speech in Real Time

December 21, 2009

(PhysOrg.com) -- By implanting an electrode into the brain of a person with locked-in syndrome, scientists have demonstrated how to wirelessly transmit neural signals to a speech synthesizer. The "thought-to-speech" process ...

1 comment

Adjust slider to filter visible comments by rank

Display comments: newest first

ubavontuba
1 / 5 (1) Apr 24, 2010
What happened to Alzheimer's being caused by herpes simplex virus type 1 (HSV1)? Might a vaccine against HSV1 be more effective?

See:

http://www.physor...732.html

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.