New biomarkers for predicting the spread of colon cancer

Jan 13, 2010
With colon cancer a leading cause of cancer death, scientists have discovered two blood proteins that may help predict whether the disease will spread. Credit: Wikimedia Commons, American Cancer Society.

Scientists in China are reporting discovery of two proteins present in the blood, of people with colon cancer that may serve as the potential biomarkers for accurately predicting whether the disease will spread. Their study is in ACS' Journal of Proteome Research.

Maode Lai and colleagues note that in 2008, 150,000 new cases of colon cancer and over 50,000 deaths from the disease occurred in the United States alone. Surgery is the main method of treating the disease. However, half of colon cancer patients undergoing surgery develop a recurrence of the disease within 5 years due to its spread, or metastasis, to other parts of the body. The spread of colon cancer can be difficult to detect and there are currently no reliable chemical markers in the body for predicting its spread, the scientists say.

In an effort to identify useful biomarkers for tracking the spread of colon cancer, the scientists compared proteins produced by primary, or original, tumor cells to those of metastasized cells came from a single individual with colon cancer. They identified two proteins that occurred at significantly higher levels in the metastatic cells than in the primary cancer cells. The two proteins could serve as potential biomarkers in a blood test for predicting the spread of , allowing earlier intervention and treatment, the scientists say.

Explore further: Natural plant chemicals could help fight tooth decay, study shows

More information: "Identification of serum biomarkers for colorectal cancer metastasis using a differential secretome approach", pubs.acs.org/doi/full/10.1021/pr9008817

Related Stories

Heart drugs show promise for fighting colon cancer

Dec 16, 2009

Scientists in Sweden are reporting for the first time that a group of drugs used to treat heart failure shows promise for fighting colon cancer. The study is in ACS' Journal of Natural Products. Colon cancer ...

Scientists discover new gene responsible for spread of cancer

Mar 29, 2006

Scientists at the University of Liverpool have identified a new gene that causes the spread of cancer. Professor Philip Rudland, Dr Guozheng Wang and Dr Roger Barraclough from the University’s Cancer and Polio Research ...

Novel marker of colon cancer

Oct 23, 2008

Colon cancer ranks second of all gastrointestinal malignant tumors, it is one of the leading causes of cancer-related deaths worldwide. Until now, several molecules have been reported to play an important role in gastroenterological ...

Surgery not necessary for most late-stage colorectal cancers

May 31, 2009

A new study shows that a large majority of patients who present with advanced colorectal cancer that has spread to other organs (stage IV) don't require immediate surgery to remove the primary tumor in the colon. Researchers ...

Recommended for you

What happens inside a membrane

May 20, 2015

A new SISSA study has achieved two important results with a single effort: to devise an innovative method to analyse the structure of biological proteins immersed in their physiological context, and to closely ...

Biomedical sensors for disease detection made simple

May 19, 2015

Healthcare researchers are increasingly focused on the early detection and prevention of illnesses. Early and accurate diagnosis is vital, especially for people in developing countries where infectious diseases ...

Studying dynamics of ion channels

May 18, 2015

Scientists from the Vaziri lab at the Vienna Biocenter, together with colleagues at the Institute for Biophysical Dynamics at the University of Chicago, have developed a method using infrared spectroscopy ...

Solving streptide from structure to biosynthesis

May 16, 2015

Bacteria speak to one another using peptide signals in a soundless language known as quorum sensing. In a step towards translating bacterial communications, researchers at Princeton University have revealed ...

User comments : 0

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.