Developing a safer form of acetaminophen

Jul 15, 2009
Scientists are reporting development of a new process for producing large batches of a new and potentially safer form of the common pain-reliever acetaminophen. Credit: Wikimedia Commons

Scientists in Louisiana are reporting development of a process for producing large batches of a new and potentially safer form of acetaminophen, the widely used pain-reliever now the source of growing concern over its potentially toxic effects on the liver. Their study, which could speed development of a next-generation pain-reliever, is scheduled for the July 17 issue of ACS' Organic Process Research & Development.

In June, an advisory panel of the U. S. Food and Drug Administration recommended banning certain prescription pain relievers containing acetaminophen because of the drug's potential to cause damage when used in high doses. Mark Trudell and colleagues note in the study that scientists recently discovered a new form of that has similar potency to the original drug with a lower risk of liver toxicity. But until now, scientists have had difficulty producing this substance in quantities suitable for industrial scale-up.

The researchers describe a simple, efficient method for producing the new pain-reliever using only a few starting materials and a short series of chemical reactions. In laboratory studies, they used the new method to produce multigram quantities of the substance with 99 percent purity. The scientists point out that the new process can be performed on a much larger production level if needed.

More information: "First Multigram Preparation of SCP-123, A Novel Water-Soluble Analgesic," Organic Process Research & Development

Source: American Chemical Society (news : web)

Explore further: A closer look at a deadly bacterium sets the stage for new vaccines

Related Stories

Questions and answers about pain medicine dangers

Jul 07, 2009

(AP) -- A Food and Drug Administration panel has recommended limits on Tylenol and other drugs containing acetaminophen because of risks for liver failure. Maximum recommended doses for over-the-counter Tylenol would be ...

FDA group recommends acetaminophen liver warnings

May 27, 2009

(AP) -- A Food and Drug Administration report released Wednesday recommends stronger warnings and dose limits on drugs containing the painkiller acetaminophen, citing an increased risk of liver injury.

Recommended for you

What happens inside a membrane

May 20, 2015

A new SISSA study has achieved two important results with a single effort: to devise an innovative method to analyse the structure of biological proteins immersed in their physiological context, and to closely ...

Biomedical sensors for disease detection made simple

May 19, 2015

Healthcare researchers are increasingly focused on the early detection and prevention of illnesses. Early and accurate diagnosis is vital, especially for people in developing countries where infectious diseases ...

Studying dynamics of ion channels

May 18, 2015

Scientists from the Vaziri lab at the Vienna Biocenter, together with colleagues at the Institute for Biophysical Dynamics at the University of Chicago, have developed a method using infrared spectroscopy ...

User comments : 0

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.