Infiltrating blood-derived macrophages play a role in recovery from spinal cord injury in mice

July 28, 2009

Although macrophages are known as essential players in wound healing, their contribution to recovery from spinal cord injury is a subject of debate.

Using a mouse model of spinal injury, Michal Schwartz and colleagues from the Weizmann institute of Science, Rehovot, Israel tested the effect of macrophages on the recovery process after injury and demonstrate an important anti-inflammatory role for a subset of infiltrating monocyte-derived macrophages that is dependent upon their expression of the anti-inflammatory molecule interleukin-10.

These results suggest that this subset of macrophages may have a beneficial effect on injuries.

More information: Shechter R, London A, Varol C, Raposo C, Cusimano M, et al. (2009) Infiltrating Blood-Derived Macrophages Are Vital Playing an Anti-inflammatory Role in Recovery from Spinal Cord Injury in Mice. PLoS Med 6(7): e1000113. doi:10.1371/journal.pmed.1000113, http://medicine.plosjournals.org/perlserv/?request=get-document&doi=1000113

Source: Public Library of Science (news : web)

Explore further: Enabling nerve regeneration means evicting the cleanup crew

Related Stories

Enabling nerve regeneration means evicting the cleanup crew

February 28, 2007

Macrophages are the immune cells that engulf and destroy the debris of damaged tissue to enable the healing process to begin. Their presence at the scene of damage is critical, but once their task is complete, it is just ...

Stem cells used to reverse paralysis in animals

January 28, 2009

A new study has found that transplantation of stem cells from the lining of the spinal cord, called ependymal stem cells, reverses paralysis associated with spinal cord injuries in laboratory tests. The findings show that ...

Recommended for you

How the finch changes its tune

August 3, 2015

Like top musicians, songbirds train from a young age to weed out errors and trim variability from their songs, ultimately becoming consistent and reliable performers. But as with human musicians, even the best are not machines. ...

Cow embryos reveal new type of chromosome chimera

May 27, 2016

I've often wondered what happens between the time an egg is fertilized and the time the ball of cells that it becomes nestles into the uterine lining. It's a period that we know very little about, a black box of developmental ...

Shaving time to test antidotes for nerve agents

February 29, 2016

Imagine you wanted to know how much energy it took to bike up a mountain, but couldn't finish the ride to the peak yourself. So, to get the total energy required, you and a team of friends strap energy meters to your bikes ...

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.