Nasal Spray May End Dental Needle Injections for Upper Teeth Repair

Feb 17, 2009

(PhysOrg.com) -- A nasal spray shown to numb the upper jaw is set to be tested in an FDA Phase 3 trial, which will assess the spray's effectiveness compared to the current "gold standard" treatment -- painful anesthesia injections.

"A successful trial of this new dental anesthetic will change dental technology worldwide," said Sebastian Ciancio, D.D.S., University at Buffalo SUNY Distinguished Service Professor and chair of the Department of Periodontics and Endodontics.

Ciancio directed the Phase 2 trial and will coordinate the Phase 3 trial. Between 6 and10 million dental needle injections are given daily, according to Ciancio.

Results of the FDA Phase 2 trial, conducted in 48 subjects at the UB School of Dental Medicine, showed that the spray appears to be safe and effective.

The Phase 3 trial will be carried out later in 2009 at the UB dental school and other clinical sites. Ciancio said that if the Phase 3 trial is successful, it may mean the end of injections for any dental work performed on the upper teeth.

Ciancio and colleagues conducted the initial preliminary dental studies using the nasal spray, which is being developed by St. Renatus, LLC, based in Fort Collins, Colo.

The nasal spray formula being tested is related to a drug used by ear, nose and throat physicians when they operate on the nose. Patients who received this anesthetic reported that their upper teeth felt numb, sparking interest in using the anesthetic for dental procedures. The spray is effective only on the upper teeth.

Provided by University at Buffalo

Explore further: Prescription drug monitoring programs offer multiple benefits

Related Stories

Research shows 'mulch fungus' causes turfgrass disease

58 minutes ago

Inadvertently continuing a line of study they conducted about 15 years ago, a team of Penn State researchers recently discovered the causal agent for an emerging turfgrass disease affecting golf courses around ...

Study on pesticides in lab rat feed causes a stir

2 hours ago

French scientists published evidence Thursday of pesticide contamination of lab rat feed which they said discredited historic toxicity studies, though commentators questioned the analysis.

Experiments open window on landscape formation

2 hours ago

University of Oregon geologists have seen ridges and valleys form in real time and—even though the work was a fast-forwarded operation done in a laboratory setting—they now have an idea of how climate ...

To conduct, or to insulate? That is the question

2 hours ago

A new study has discovered mysterious behaviour of a material that acts like an insulator in certain measurements, but simultaneously acts like a conductor in others. In an insulator, electrons are largely stuck in one place, ...

Recommended for you

FDA clears drug for leading form of cystic fibrosis

Jul 02, 2015

Federal health officials have approved a new combination drug for the most common form of cystic fibrosis, the debilitating inherited disease that causes internal mucus buildup, lung infections and early death. But it will ...

User comments : 0

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.