What is the risk factor for gastric cancer in a Costa Rican?

Jan 21, 2009

A research group from Costa Rican evaluated risk factors for gastric cancer in Costa Rican regions with contrasting gastric cancer incidence rates (GCIR). They found that although a pro-inflammatory cytokine genetic profile showed an increased risk for developing gastric cancer (GC), the characteristics of Helicobacter pylori (H. pylori) infection, in particular the status of cagA and vacA genotype distribution seemed to play a major role in GCIR variability in Costa Rica.

Costa Rica, one of the countries with the highest age-adjusted incidence and mortality rates for gastric cancer (GC), has regions with contrasting gastric cancer incidence rate (GCIR). Helicobacter pylori (H. pylori) is a Gram-negative microaerobic bacterium that persistently colonizes the human gastric mucosa. There is an increased GC risk in subjects infected with H. pylori strains, especially those co-expressing the cagA, vacA s1 and babA2 genes. Cytokine gene polymorphisms of the host, IL-1beta, IL-1RN and IL-10, in response to H. pylori infection, have been also associated with an increased risk for developing gastric cancer.

A research team led by Dr. Sergio A Con from Costa Rica evaluated the potential impact of H. pylori and/or host genetic factors on GCIR variability in Costa Rica. Their study will be published on January 14, 2009 in the World Journal of Gastroenterology.

In their study, 191 H. pylori-positive patients were classified into groups A (high GCIR, n = 101) and B (low GCIR, n = 90). Human DNA obtained from biopsy specimens was used in the determination of polymorphisms of the genes coding for interleukin (IL)-1beta and IL-10 by PCRRFLP, and IL-1RN by PCR. H. pylori DNA extractions obtained from clinical isolates of 83 patients were used for PCR-based genotyping of H. pylori cagA, vacA and babA2.

They found that cytokine polymorphisms showed no association with GCIR variability. However, gastric atrophy, intestinal metaplasia and strains with different vacA genotypes in the same stomach (mixed strain infection) were more frequently found in group A than in group B, and cagA and vacA s1b were significantly associated with high GCIR (P = 0.026 and 0.041, respectively).

Their result indicated that although a pro-inflammatory cytokine genetic profile showed an increased risk for developing GC, the characteristics of H. pylori infection, in particular the status of cagA and vacA genotype distribution seemed to play a major role in GCIR variability in Costa Rica.

Source: World Journal of Gastroenterology

Explore further: Tumor surroundings are shown to affect progression of different cancer subtypes

Related Stories

NSA winds down once-secret phone-records collection program

1 hour ago

The National Security Agency has begun winding down its collection and storage of American phone records after the Senate failed to agree on a path forward to change or extend the once-secret program ahead of its expiration ...

Pipeline that leaked wasn't equipped with auto shut-off

1 hour ago

The pipeline that leaked thousands of gallons of oil on the California coast was the only pipe of its kind in the county not required to have an automatic shut-off valve because of a court fight nearly three ...

Uber drivers fined in Hungary

2 hours ago

The Hungarian tax authority fined Uber drivers in its first probe against the ride-sharing service which the economy ministry said Saturday "ignores passenger safety" and must be made to follow regulations.

Recommended for you

Diagnosing cancer with help from bacteria

14 hours ago

Engineers at MIT and the University of California at San Diego (UCSD) have devised a new way to detect cancer that has spread to the liver, by enlisting help from probiotics—beneficial bacteria similar to ...

User comments : 0

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.