Absence of CLP protein can be indicative of oral cancer

Jan 07, 2009

Human calmodulin-like protein (CLP) is found in many cell types including breast, thyroid, prostate, kidney, and skin. The protein can regulate many cell activities and has a highly specific expression. Gaining an understanding about the expression of CLP in oral epithelial cells and its possible downregulation (or lack of production) in cancer may be a potentially valuable marker in early detection of oral cancer. A new study in the Journal of Prosthodontics found that CLP is expressed in normal human oral muscosal cells and that downregulation of this protein may be an indicator of malignancy or cancer.

Michael D. Brooks, DMD, MS, Richard D. Bennett, PhD, Emanuel E. Strehler, PhD, Thomas J. Sebo, MD, PhD, Stephen E. Eckert, DDS, MS, and Alan B. Carr, DMD, MS used a method of staining oral skin cells to see if they expressed this protein. A breast tissue sample that was known to have this protein was used as a basis for comparison. Normal cells in the mouth also possessed CLP. In malignancy or cancer, the same type of skin cells no longer expressed this protein.

In the areas of cancerous cells, a decrease in CLP occurred. There was a sharp contrast in staining quality and clarity between benign and malignant tissue. In the majority of the cancerous regions, a complete lack of CLP was noted.

This may be significant because calmodulin-like protein could be a marker for normal healthy oral cavity cells and diminished or complete loss of the protein could be an indicator of oral cancer or oral cancer development.

"Perhaps a non-invasive method could be developed to screen for oral cancer," the authors note. "Unlike other screening methods that attempt to mark actual cancer cells, this marker would show in healthy cells and would decrease only in cancer transformation."

Source: Wiley

Explore further: Spicy treatment the answer to aggressive cancer?

Related Stories

Nano-hydrogels that attack cancer cells

Feb 06, 2015

Hydrogels are materials that are commonly used in everyday objects such as contact lenses or diapers, in order to control humidity. However, chemical engineers at the University of Guadalajara (UdeG), in ...

New type of cell movement discovered

Aug 28, 2014

For decades, researchers have used petri dishes to study cell movement. These classic tissue culture tools, however, only permit two-dimensional movement, very different from the three-dimensional movements ...

Recommended for you

Spicy treatment the answer to aggressive cancer?

Jul 03, 2015

It has been treasured by food lovers for thousands of years for its rich golden colour, peppery flavour and mustardy aroma…and now turmeric may also have a role in fighting cancer.

Cancer survivors who smoke perceive less risk from tobacco

Jul 02, 2015

Cancer survivors who smoke report fewer negative opinions about smoking, have more barriers to quitting, and are around other smokers more often than survivors who had quit before or after their diagnosis, according to a ...

Melanoma mutation rewires cell metabolism

Jul 02, 2015

A mutation found in most melanomas rewires cancer cells' metabolism, making them dependent on a ketogenesis enzyme, researchers at Winship Cancer Institute of Emory University have discovered.

User comments : 1

Adjust slider to filter visible comments by rank

Display comments: newest first

E_L_Earnhardt
not rated yet Jan 08, 2009
GOOD WORK! CONTINUE PLEASE!

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.