The symptoms of T-cell leukemia/lymphoma

Dec 01, 2008

Multiple lymphomatous polyposis (MLP) is an unusual form mantle cell lymphoma characterized by polyps throughout the gastrointestinal tract. Adult T-cell leukemia/lymphoma (ATLL) is a malignancy associated with retrovirus, human T-cell lymphotropic virus type 1 (HTLV-1). Although it is well-known that ATLL cells infiltrate into systemic organs including gastrointestinal (GI) tract, colonic involvement has not been fully documented.

A research team led by Dr. Akira Hokama from University of the Ryukyus, reported a case of a 66-year-old man with adult T-cell leukemia/lymphoma (ATLL). This will be published on November 14, 2008 in the World Journal of Gastroenterology.

A 48-year-old man presented with fever and watery diarrhea of a history for three weeks. He had
been diagnosed as having smouldering ATLL with erythematopapular cutaneous lesions, in which
monoclonal integration of proviral DNA of HTLV-1 into the host genome was confirmed by the Southern blot analysis. He had been managed conservatively without leukemic change or visceral invasion for 20 years. Strongyloides stercoralis were negative. Colonoscopy disclosed multiple whitish polyps throughout the colon. Indigo carmine dye spraying showed a central depression on the polyps. Pedunculated colonic mucosal tissue was replaced by diffuse proliferation of large lymphoid cells with pleomorphic nuclei and pale cytoplasmAbdominal examination showed hyper bowel sounds, but no hepatosplenomegaly. The patient died despite combination of chemotherapy 3 moth later.

Although this case is rare, ATLL should be included in the differential diagnosis of MLP. They emphasize the importance of endoscopic evaluation to differentiate neoplastic intestinal lesions from infectious enterocolitis for abdominal symptoms in patients with leukemia/lymphoma.

Source: World Journal of Gastroenterology

Explore further: Human stem cell model reveals molecular cues critical to neurovascular unit formation

Related Stories

Great white shark cruising East Coast becomes Twitter star

2 hours ago

They're gonna need a bigger Twitter. An organization studying great white sharks is enjoying some welcome attention after one of the creatures they've been monitoring started gaining a loyal social media following. @MaryLeeShark ...

New Japan volcano island 'natural lab' for life

17 hours ago

A brand new island emerging off the coast of Japan offers scientists a rare opportunity to study how life begins to colonise barren land—helped by rotting bird poo and hatchling vomit.

Recommended for you

Scientists turn blood into neural cells

May 21, 2015

Scientists at McMaster University have discovered how to make adult sensory neurons from human patients simply by having them roll up their sleeve and providing a blood sample.

User comments : 0

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.