Large hormone dose may reduce risk of post-traumatic stress disorder

Oct 27, 2008

A new study by Ben-Gurion University of the Negev (BGU) researchers found that a high dose of cortisone could help reduce the risk of post-traumatic stress disorder (PTSD). The article appears in Biological Psychiatry, Volume 64, Issue 8 (October 15, 2008), pages 708-717.

In an animal model of PTSD, high doses of a cortisol-related substance, corticosterone, prevented negative consequences of stress exposure, including increased startle response and behavioral freezing when exposed to reminders of the stress.

Cortisol is secreted into the blood stream through the adrenal glands, which are active when the body responds to stress. It is known as "the stress hormone" because it is also secreted in higher levels during the body's "fight or flight" response to stress, and is responsible for several stress-related changes in the body.

According to Dr. Hagit Cohen of the Anxiety and Stress Research Unit at the Faculty of Health Sciences, Ben-Gurion University of the Negev, "A single intervention with high-dose corticosterone immediately after exposure to a psychogenic stressor was highly effective in reducing the incidence of PTSD-like behaviors and improved the resilience to subsequent trauma-cue exposure in an innovative controlled prospective animal study."

"Single high-dose corticosteroid treatment may thus be worthy of clinical investigation as a possible avenue for early pharmaco-therapeutic intervention in the acute phase, aimed at prevention of chronic stress-related disorders, such as PTSD," Cohen explains. "In this sense, it brings treatment of PTSD to a new era – an era of secondary prevention, an era of the golden hours."

Source: American Associates, Ben-Gurion University of the Negev

Explore further: Pentagon: Anthrax shipments broader than first thought

Related Stories

Guns aren't the only things killing cops

Apr 11, 2014

The public does not realize—in fact, police themselves may not realize—that the dangers police officers are exposed to on a daily basis are far worse than anything on "Law and Order."

Mobile phones may make us healthier, research suggests

Feb 19, 2013

(Phys.org)—More than 6 billion people worldwide (including almost 400 million in the United States) now carry mobile phones, which could be used to enhance mental and physical health, a Cornell researcher proposes.

Recommended for you

Pentagon: Anthrax shipments broader than first thought

11 hours ago

The Pentagon said Friday that the Army's mistaken shipments of live anthrax to research laboratories were more widespread than it initially reported, prompting the Defense Department's second-ranking official ...

Anthrax shipments came from military site in Utah desert

May 29, 2015

The U.S. Army's mistaken shipment of live anthrax samples to government and commercial laboratories occurred at a military post in a desolate stretch of the Utah desert that has been testing chemical weapons ...

User comments : 0

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.